A man is fighting serious injuries in hospital after he was shot during a home invasion in Melbourne’s north-west overnight.

Multiple offenders broke into a house in Gladstone Park just before 1.30am where a couple were sleeping inside, police allege.

It is believed the intruders were confronted by a 60-year-old man, who was then shot and assaulted with weapons.

It's alleged multiple offenders broke into a house on Trentham Drive in Gladstone Park just before 1.30am where a couple were sleeping insideIt’s alleged multiple offenders broke into a house on Trentham Drive in Gladstone Park just before 1.30am where a couple were sleeping inside. (Nine)Detectives from the forensics team examined the scene today.Detectives from the forensics team examined the scene today. (Nine)

He sustained serious injuries from the gunshot wound and was rushed to hospital.

A 57-year-old woman was threatened with a gun but was not physically injured, police said.

The offenders fled the scene in a white Haval SUV and remain on the run.

Investigators believe the incident was targeted.

Detectives from the forensics team were seen examining the scene today.