A southbound section of State Highway 2 near Pāpāmoa is closed after a serious crash that injured five people.

Police said they were alerted to the two-vehicle crash about 3.40pm.

Police said one person had received serious injuries, while two others sustained moderate to minor injuries.

The southbound lanes are blocked between Sandhurst Drive and Domain Rd and the NZ Transport Agency advised motorists to expect delays and pass the scene with care.

A driver who called SunLive said traffic was backing up on the highway.

A Hato Hone St John spokesperson said it assessed five patients at the scene.

Three, all in moderate condition, were being taken to Tauranga Hospital.

The two remaining patients, both with minor injuries, were treated at the scene and did not need ambulance transport.