Former Arsenal player Dinos Mavropanos will play as the right centre-back. The Greek joined the Gunners from PAS Giannina in January 2018 and played eight games for the club before moving to German club Stuttgart in 2022.
Mavropanos will be partnered by Maximilian Kilman, who has tasted victory at Emirates Stadium with both Wolverhampton Wanderers and West Ham.
The midfield will be anchored by Frenchman Soungoutou Magassa, who keeps his place after making an impressive full debut at Everton. The 21-year-old started Monaco’s UEFA Champions League league-stage tie at Emirates Stadium last season.
Portuguese Mateus Fernandes registered an assist in each of Southampton’s two Premier League meetings with Arsenal last season.
Brazil’s Lucas Paquetá has two goals in six Premier League games this season. He started West Ham’s Premier League win over Arsenal here and EFL Cup victory at London Stadium in 2023/24.
The substitutes’ bench sees one change, with Walker-Peters taking the place of Andy Irving, who misses out.
The suspended Tomáš Souček, James Ward-Prowse, former Arsenal goalkeeper and FA Cup winner Łukasz Fabiański and injured midfielder George Earthy are also not involved.
On the bench, Nuno will again be assisted by Mark Robson, Steve Potts, Gerard Prenderville and goalkeeper coach Billy Lepine, all of whom have extensive experience working at the Academy of Football.
Arsenal: Raya, Timber, Saliba, Gabriel, Calafiori, Rice, Saka, Trossard, Ødegaard ©, Eze, Gyökeres
Subs: Kepa (GK), White, Lewis-Skelly, Mosquera, Nørgaard, Nwaneri, Zubimendi, Martinelli, Merino
West Ham United: Areola, Wan-Bissaka, Mavropanos, Kilman, Diouf, Magassa, Fernandes, Paquetá, Bowen ©, Summerville, Füllkrug
Subs: Hermansen (GK), Walker-Peters, Scarles, Igor, Potts, Rodríguez, Luis Guilherme, Marshall, Wilson
Referee: John Brooks