Twelve engines and five brigade response vehicles attended,
The fire service said it checked every room of the hotel, carrying out a floor-by-floor search and there were no further casualties.
The blaze was confirmed to be out shortly before 04:10 and crews then cleared any remaining pockets of smoke.
Ms Lewis said the hotel’s alarms had gone off so guests were “awake and aware something was happening” and crews supported staff to make sure everyone was safe.
“The Premier Inn themselves were really good and confirming who was in the building, what rooms they were in and then obviously finding a second location for them to be moved to for safety,” she said.
Asked about the challenges for crews, she added: “It was the middle of the night, obviously the city centre has still probably got people that were out enjoying the evening, so it was just a case of being able to manage the people [and] the resources.
“We ended up closing the road off because of the number of appliances that we had.”