A 17-year-old boy has been charged with murder after an altercation between two groups left a man dead at a popular nightlife spot.

The incident occurred at 11.45pm on Saturday after two groups of people clashed on Morrison St in the Salamanca entertainment district in Tasmania’s capital city.

Police believe it was linked to a previous incident involving a person from each group.

File image: The Salamanca entertainment precinct in Hobart. The Salamanca entertainment precinct in Hobart is popular with locals and tourists, with pubs, bars and clubs in the area. (Getty)

As a result of the altercation, two men – one aged 20 and one aged 23 – were stabbed.

The 20-year-old man died at the scene, whilst the other man remains in hospital with non-life-threatening injuries.

Police commenced an investigation, and have now charged a 17-year-old boy with multiple offences.

As well as murder, he was charged with wounding and assault.

He will appear in the Youth Justice Court in Hobart today.

Previously, police had taken a 20-year-old man into custody, who was said to be cooperating with investigators.

However, at this stage charges have not been laid against that man or anyone else in relation to the stabbings.

Police are still urging any potential witnesses ot anyone with information who may not have spoken to investigators to come forward.

Information can be provided to South East Criminal Investigation Branch on 131 444 or anonymously through Crime Stoppers Tasmania at crimestopperstas.com.au or on 1800 333 000