Note that the lists of working group members are organized alphabetically by last name. We also highlight that these lists are not exhaustive with respect to the members of the working groups; rather, they reflect individual members of the working groups who approved the contents of this Article. A.D.G., J.W., W.J.P. and O.F. conducted the primary analyses presented in the paper for GenomicSEM, LAVA, CC-GWAS and MiXeR, respectively. L.K.B., Q.G., M.P.M. and J.W. ran the functional follow-up analyses. O.F. and R.E.P. ran and provided feedback on cross-ancestry and diverse ancestry genome-wide analyses. B.J.C., A.B., V.P. and J.M.B. conducted the phenome-wide association study analyses. C.d.L., E.M.T.-D. and P.H.L. provided additional feedback on the analyses and included data. A.D.G., J.W., W.J.P., O.F., K.S.K. and J.W.S. wrote the initial draft of the manuscript. K.S.K. and J.W.S. jointly supervised the research. All of the named authors provided iterative feedback on the manuscript, including O.A.A., V.A., A.D.B., G.B., N.C., D.D., H.J.E., S.V.F., B.F., M.J.G., J.G., A.S.H., J.M.H., E.C.J., T.T.M., M.M., K.S.M., B.M.N., C.M.N., J.I.N., K.S.O., E.B.R., S.S.S.-R., S.L.S., J.M.S., H.S., K.S., M.B.S., N.I.S., L.M.T., B.V., I.D.W., G.B.W., N.R.W. and D.Y. All of the collaborators within the listed working group banners approved the contents of the manuscript.