Wintry weather is sweeping across parts of the United States this weekend, bringing with it brutally low temperatures.

Sixty million people from the Northern Plains through the Southeast are under cold weather alerts, including Minneapolis, Chicago, St. Louis, Memphis, Huntsville and Myrtle Beach.

Dangerously cold wind chills are expected to hit these areas, with the National Weather Service issuing some alerts that run into Monday morning.

People in the snow.People walk in cold weather along the Brooklyn Bridge on Dec. 8 in New York City.Spencer Platt / Getty Images

The most extreme temperatures will hit the Northern Plains and Midwest on Saturday night, where overnight temperatures could dip as low as -25 degrees.

Wind chills will make it feel like -30 to -35 degrees in the Dakotas, Minnesota and Wisconsin.

By Monday morning, wind chills in the teens and single digits will stretch into the Mid-South and Southeast, with the Gulf Coast forecast to see wind chills in the 20s.

Record low temperatures are expected over the next couple of mornings in parts of Illinois, Indianapolis, South Carolina, Alabama and Georgia.

Daytime highs will stay 10 to 35 degrees below average along and east of the Plains, with highs expected to stay below zero in the Northern Plains Saturday afternoon.

On Sunday, highs will stay in the single digits, teens and 20s across much of the Midwest, Northeast and Mid-South.

Snow from the Plains through the Mid-Atlantic

Sixty-eight million people from the Plains through the Mid-Atlantic face winter alerts, some of which will last through Sunday midday.

A quick-moving clipper is bringing periods of heavy snow and gusty winds to these areas.

People play in the snow.People sled down one of the hills at the Cherokee Park golf course in Louisville, Ky., after the metro area was covered with a few inches of snow Dec. 12,.Matt Stone / USA Today Network via Imagn Images

Some of the cities facing these alerts are Sioux Falls, the Quad Cities, Indianapolis, Cincinnati, Cleveland, Philadelphia and New York.

Snow showers were already hitting parts of Iowa, Illinois and Indiana on Saturday morning. This cluster will zip through the Midwest on Saturday afternoon, reaching parts of the Ohio Valley and Appalachians by the evening.

A video taken in Iowa City on Saturday morning shows a heavy blanket of snow covering the ground.

These showers will move into the Mid-Atlantic overnight, with snow lingering in Washington, D.C., Philadelphia, New York and Boston through Sunday morning.

Snowfall will gradually come to an end by the mid-afternoon on Sunday, as the system moves offshore.

A swath of 2 to 5 inches of snow is possible in parts of central Iowa and Illinois through the Appalachians.

Totals for the I-95 corridor will range from 1 to 4 inches from Washington, D.C. through Boston, with higher localized amounts possible across New Jersey and Long Island.

Lake-effect snow bands are forecast to develop downwind of Lake Erie and Ontario through the weekend.

Lake-effect snow warnings are in place through Monday, as 7 to 14 inches of snow is possible accompanied by 35 mph wind gusts, which will create difficult travel conditions.

Cars in the snow.Drivers navigate across snowy roadways on Dec. 11 in Des Moines.Cody Scanlan / USA Today Network via Imagn Images Flooding in the Northwest

After a rain-soaked few days, the Northwest will catch a dry break Saturday thanks to an area of high pressure.

Significant river flooding will persist through the area, most notably in western Washington.

The possibility of rain will return on Sunday, with another strong storm moving onshore Monday into Tuesday. This system is set to bring another round of heavy precipitation and strong winds.