There will be more trains to London, Doncaster, Wakefield, Leeds and Bradford Forster Square, with faster journey times, according to LNER.
Gareth Dennis, a railway engineer and writer, said the changes had been five years in the making.
“It’s taken that long for all the parties to actually finally agree on what that service should look like,” he said.
“But also the reason there’s such a dramatic change is because in that time we have had major civil engineering works, so lots of projects to help the railway have more capacity to run more trains.”
The changes are the biggest on the railway network since May 2018 when a timetable update led to weeks of chaos on the Northern and Govia Thameslink Railway (GTR) networks.
Mr Dennis said railway companies had been told by government to “prioritise reducing end-to-end journey times and increasing the number of intercity services”.
“If you’re travelling to Newcastle, if you’re travelling to Leeds, if you’re travelling to York, you are going to see an improvement in service, increase in the frequency of your trains and a little bit of improvement in journey times as well.”
He added: “The biggest challenge is reliability, but after that, it’s capacity. The East Coast Main Line is now full.
“We can’t squeeze another drop out of this railway. It is spectacular what we are achieving out of it.”