A driver is being treated in hospital for a serious head injury after their car hit the central reservation on the M62.
Humberside Police said a blue Vauxhall Corsa crashed on the M62 westbound between junctions35 and 34 at 21:45 GMT on Friday.
Officers believe the vehicle came to a stop after the initial incident before it was then hit by a black Volvo.
The driver and passenger of the Volvo, a 36-year-old man and a 39-year-old woman, were also taken to hospital, but police said their injuries were not thought to be serious.