Demko made just three saves on six shots before exiting. Backup Kevin Lankinen took his place between the pipes.
Earlier Sunday, the Canucks recalled goalie Nikita Tolopilo from AHL Abbotsford under emergency conditions.
Demko, a Vezina Trophy finalist in 2024, has a .902 save percentage and 2.79 goals-against average with one shutout for the 32nd-place Canucks prior to Saturday night.
Vancouver returns to action Monday with a visit to the Montreal Canadiens.