Crook said local residents had been “really welcoming” to the cast and crew.
Sally Sadler said she found out her house was going to be a part of the series while out food shopping.
“It was by text [and] I was in the supermarket,” she said. “One of my neighbours told me Mackenzie Crook was on the drive next door.
“It’s been amazing to be honest – it’s been bizarre at points and surreal when you’re seeing people staggering down the avenue pretending to be drunk and manure being delivered and all this greenery arriving next door.”
Cast member Lauren Patel, who memorably voiced PC Mukherjee in the recent Wallace and Gromit hit, added: “Being able to film in Manchester where I’ve grown up and being able to have so many incredible people from the North working on it has been really cool.”
Pearce added that had “seen more of my mum than I would have done normally”, adding: “I love being back home in Manchester.”
Small Prophets will be shown on BBC Two at 22:00 GMT on Monday 9 February and will also be available to watch on the BBC iPlayer