Festival headliners include 90s electronic pioneers The Prodigy, pop songstress Raye, and rapper Central Cee.
Also taking to the stage across the weekend are indie band Kaiser Chiefs, chart-topping singer Natasha Bedingfield, and hip-hop duo Rizzle Kicks.
Campsites and car parks are due to open at 10:00 BST and will close at 12:00 on Monday.
The festival is spread over two locations with the main arena and campsites at Watergate Bay, whilst Fistral Beach hosts the Boardmasters Open, surf competition and shopping village.
A one-way traffic system and soft road closures have also been introduced to reduce the impact during peak arrival and departure times.