A haul of 29 weapons, including a knuckleduster, was also confiscated.
In Wiltshire specifically, 26 people were arrested and £380,000 worth of drugs seized. Meanwhile in Gloucestershire, two people were arrested and £37,000 worth of cocaine seized.
In Bristol and Somerset, specific drug raids were carried out and work is under way with local schools to raise awareness of the risks of being involved in distributing drugs.
Coles continued: “Criminal gangs that are involved in county lines activity often adapt their strategies to exploit young people and vulnerable individuals.
“We see some of those local lines being led by more upstream county lines, but it is vital we understand the way county lines are using vulnerable children within Wiltshire. They can also force them to transport drugs and money across our county and other counties.”