The new series will explore the aftermath of World War Two on the city as it follows the “older, wiser, more ambitious and more dangerous” Duke.
It will also feature the TV debut of actor Lucy Karczewski.
Knight said: “I am thrilled that we are announcing a new era of Peaky Blinders, moving the story to post-war Birmingham in the early 50s.
“We are incredibly fortunate to have Jamie Bell taking the role of Tommy Shelby’s oldest son, Duke, and to have Charlie Heaton also leading the cast.
“There are more exciting cast announcements to come, and Peaky is on the road again.”