The Whites were beaten 2-0 by Stockport County on the opening day despite creating several good opportunities in the final third.
More than 20,000 tickets have been sold for Saturday’s fixture as Steven Schumacher prepares to face his former club.
Team news
Bolton have no new injuries from the Stockport defeat and Sam Dalby could be back in training in some capacity next week.
The striker arrived on a free transfer from Wrexham over the summer but suffered a hamstring injury in the early stages of pre-season.
A number of first-team players got minutes for the B Team on Tuesday afternoon including Ethan Erhahon and Thierry Gale.
Plymouth striker Bim Pepple could be involved after missing the opening day through injury. Midfielder Caleb Watts started up front in his absence.
Opposition lowdown
Plymouth also tasted defeat on the opening day, losing 3-1 against Barnsley at Home Park despite playing the final half hour with a man advantage.
Tom Cleverley took charge of the Devon club this summer following Miron Muslic’s departure to join Schalke.
Cleverley was in charge of Watford in the Championship last season but was axed after finishing in 14th place.
Head-to-head
The last time the sides met was the memorable Vertu Trophy final at Wembley as Wanderers secured an emphatic 4-0 victory.
Ironically, Schumacher was in the opposition dugout that day and his Plymouth side bounced back quickly to clinch the League One title.
The points were shared when the sides met at the Toughsheet Community Stadium several months prior following a goalless draw.
Bolton’s last defeat in the fixture came in August 2022 at Home Park when Niall Ennis and Ryan Hardie struck either side of half time.
Predicted line-up