A Kew East father has been stabbed 11 times, including in the face, while he defended his wife and two toddlers who were trapped in a separate room during an alleged violent home invasion.

Police said the 39-year-old man had attempted to fight off five armed home invaders who smashed a large window to break into his family home in Oxford Street at 4am on Sunday morning.

Police said a 39-year-old man was stabbed multiple times.

Police said a 39-year-old man was stabbed multiple times.Credit: Nine News

The husband and wife, 34, allegedly confronted the intruders, with the woman herded at knifepoint into a room with their two children, aged two and three, while her husband faced the intruders.

The man’s parents, who were also staying in the home, aged 69 and 70 years old, ran to his aid, but were confronted by the group and left with minor injuries. The grandfather suffered cuts to his hands, and the grandmother was “pushed around,” police said.

The invaders, allegedly armed with a machete, garden shears, and a knife, attacked the father, who was later taken to hospital with serious, non-life-threatening injuries. He suffered a broken arm and will undergo eye surgery as part of his recovery. His wife was treated for minor injuries.

Three people have been charged over a home invasion in which a Melbourne man was allegedly stabbed 11 times.

Three people have been charged over a home invasion in which a Melbourne man was allegedly stabbed 11 times.Credit: Nine News

Victoria Police charged a man and two teenage boys with multiple offences on Sunday night following the alleged burglary. Two more alleged offenders are on the run.

Detective Sergeant Leeanne Trusler said she has “never seen anything like it”.

“This is awful. A family … asleep in their home [at] nearly four o’clock in the morning, the house is secure, they’re meant to be safe and they’re woken up like this,” she said. “People’s home is their castle, you should be safe. ”