The forward lines up against his former club at Deutsche Bank Park for the league-phase fixture as the Reds make five changes.
Elsewhere, Jeremie Frimpong and Andy Robertson come back into the XI, while there are also starts for Curtis Jones and Florian Wirtz.
Liverpool: Mamardashvili, Van Dijk, Konate, Wirtz, Szoboszlai, Isak, Jones, Gakpo, Ekitike, Robertson, Frimpong.
Subs: Woodman, Misciur, Gomez, Endo, Kerkez, Mac Allister, Salah, Bradley, Chiesa, Ngumoha.