There were dangerous items at the crash site that were possibly explosive, he said. “Do not go to the site.”

Local fire chief Brian O’Neill said crews were making progress on the blaze, but there were more than 250,000 pounds of jet fuel on the plane, plus more fuel that was stored at the crash site.

Fire and smoke mark where a UPS cargo plane crashed near Louisville Muhammad Ali International Airport.

Fire and smoke mark where a UPS cargo plane crashed near Louisville Muhammad Ali International Airport.Credit: Getty Images

“We’re talking about a very, very dangerous situation,” he said. “You’ve got fuel recycling storage and some bulk fuel storage that’s right there. You also have the auto parts area. There’s a lot of issues that are going on with being able to surround and contain this fire.”

People were ordered to shelter-in-place within eight kilometres of the airport, local media reported.

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The MD-11 has capacity to carry about 38,000 gallons of fuel, or about 144,000 litres, and it would have been carrying a full load for the long flight to Honolulu.

One video posted to social media, purporting to depict the crash, showed a plane attempting to take off with a visible ball of fire on its left-wing before it crashed.

CNN reported that helicopter video from a local affiliate network showed flames in a car recycling yard and a trucking lot.

The Louisville Metro Police Department said it was responding to the crash along with multiple other agencies, and that injuries had been reported. The crash occurred near Fern Valley and Grade Lane, it said. Both roads border the southern end of the airfield.

Louisville Mayor Craig Greenberg said he was praying for the victims and told motorists to avoid the area. “We have every emergency agency responding to the scene. There are multiple injuries and the fire is still burning,” Greenberg said.

The airfield was closed and all departing and arriving flights suspended, the airport said.

Louisville International Airport is home to UPS Worldport, which the company describes as a 5.2 million square foot facility where more than 12,000 employees process more than 2 million packages a day.

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