After the break, Derry bagged himself a brace as England capitalised on a mix-up at the back between the Latvian defence, allowing the forward to tap into an empty net.
And with just over an hour played, Derry completed his hat-trick, combining with Trey Nyoni in a neat passing move which ended with Derry taking aim from the edge of the box as his effort kissed the post on its way in.
Mukasa made it two from two from the spot after England were awarded a second penalty of the game. Substitute Jeremy Monga was brought down before Mukasa confidently rolled the ball in from 12 yards – the Young Lions’ seventh.
Antwi’s team sign off their trip to Lithuania with their final fixture in the first qualifying round against Scotland on Tuesday 18 November (10am GMT kick-off).
England:Â 13 Khari Ranson (Arsenal), 2 Leo Shahar (Newcastle United), 3 Stephen Mfuni (Manchester City), 4 Trey Nyoni (Liverpool), 6 Kian Noble (Manchester City), 10 Divine Mukasa (Manchester City), 11 Chris Rigg (Sunderland), 14 Max Dowman (Arsenal), 16 Jack Fletcher (Manchester United), 17 Rio Ngumoha (Liverpool), 19 Jesse Derry (Chelsea)
Substitutes: 18 Souleymane Sidibe (PSV Eindhoven) for Rigg 46’, 15 Samuel Amissah (Fulham) for Mfuni 46’, 20 Jeremy Monga (Leicester City) for Dowman 46’, 12 Harry Amass (Sheffield Wednesday, loan from Manchester United) for Nyoni 68’, 5 Airidas Golambeckis (West Ham United) for Noble 78’
Substitutes not used:Â 1 Nicolas Michalski (Blackburn Rovers), 9 Shumaira Mheuka (Chelsea)
Head coach:Â Will Antwi
Goals: Ngumoh 2’, Mukasa 11’ 72’, Derry 23’ 52’ 62’, Rigg 40’