Kanagal-Shamanna, R., Beck, D. B. & Calvo, K. R. Clonal hematopoiesis, inflammation, and hematologic malignancy. Annu. Rev. Pathol. 19, 479–506 (2024).
Jaiswal, S. et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488–2498 (2014).
Jaiswal, S. & Ebert, B. L. Clonal hematopoiesis in human aging and disease. Science https://doi.org/10.1126/science.aan4673 (2019).
Jaiswal, S. et al. Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease. N. Engl. J. Med. 377, 111–121 (2017).
Hong, T. et al. TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells. Nat. Aging 3, 1387–1400 (2023).
Zhang, Z. M. et al. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature 554, 387–391 (2018).
Calhoun, D. A. et al. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation 117, e510–e526 (2008).
Williams, B. et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur. Heart J. 39, 3021–3104 (2018).
Carey, R. M., Sakhuja, S., Calhoun, D. A., Whelton, P. K. & Muntner, P. Prevalence of apparent treatment-resistant hypertension in the United States. Hypertension 73, 424–431 (2019).
Wu, C. et al. Prevalence and characteristics of apparent treatment-resistant hypertension in older people in China: a cross-sectional study. Clin. Exp. Hypertens. 41, 753–758 (2019).
Chan, K. K., Chiang, L., Choi, C. C., Li, Y. & Chen, C. X. Prevalence and associated risk factors of resistant hypertension among Chinese hypertensive patients in primary care setting. BMC Prim. Care 25, 120 (2024).
Xiao, X. et al. A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension. BMC Med. 20, 463 (2022).
Irvin, M. R. et al. Genome-wide association study of apparent treatment-resistant hypertension in the CHARGE consortium: the CHARGE Pharmacogenetics Working Group. Am. J. Hypertens. 32, 1146–1153 (2019).
Zhao, K. et al. Somatic and germline variants and coronary heart disease in a Chinese population. JAMA Cardiol. 9, 233–242 (2024).
Jager, R. et al. Combined effects of clonal hematopoiesis and carotid stenosis on cardiovascular mortality. J. Am. Coll. Cardiol. 83, 1717–1727 (2024).
Lin, A. E. et al. Clonal hematopoiesis of indeterminate potential with loss of Tet2 enhances risk for atrial fibrillation through Nlrp3 inflammasome activation. Circulation 149, 1419–1434 (2024).
Haring, B. et al. Clonal hematopoiesis of indeterminate potential and incident hypertension: results From the Women’s Health Initiative. Hypertension 82, e70–e72 (2025).
Cochran, J. D. et al. Clonal hematopoiesis in clinical and experimental heart failure with preserved ejection fraction. Circulation 148, 1165–1178 (2023).
Vlasschaert, C. et al. Clonal hematopoiesis of indeterminate potential and progression of CKD. J. Am. Soc. Nephrol. https://doi.org/10.1681/ASN.0000000680 (2025).
Regan, J. A. et al. Clonal hematopoiesis associates with prevalent and incident cardiometabolic disease in high-risk individuals. Preprint at medRxiv https://doi.org/10.1101/2025.01.14.25320566 (2025).
Revision Committee of Chinese Guidelines. 2018 Chinese guidelines for prevention and treatment of hypertension: a report of the Revision Committee of Chinese guidelines for prevention and treatment of hypertension. J. Geriatr. Cardiol. 16, 182–241 (2019).
Polizio, A. H. et al. Experimental TET2 Clonal hematopoiesis predisposes to renal hypertension through an inflammasome-mediated mechanism. Circ. Res. https://doi.org/10.1161/CIRCRESAHA.124.324492 (2024)
Barbaro, N. R. & Harrison, D. G. Markers or makers: inflammatory cytokines in treatment-resistant hypertension. Hypertension 73, 767–769 (2019).
Pioli, M. R. & de Faria, A. P. Pro-inflammatory cytokines and resistant hypertension: potential for novel treatments? Curr. Hypertens. Rep. 21, 95 (2019).
Polizio, A. H. et al. Clonal hematopoiesis increases hypertension and sympathetic activity and is reversed by renal denervation. Hypertension 82, e28–e30 (2025).
Svensson, E. C. et al. TET2-driven clonal hematopoiesis and response to canakinumab: an exploratory analysis of the CANTOS randomized clinical trial. JAMA Cardiol. 7, 521–528 (2022).
Yang, L. et al. DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias. Cancer Cell 29, 922–934 (2016).
Gozdecka, M. et al. Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis. Nature 642, 431–441 (2025).
Hosseini, M. et al. Metformin reduces the competitive advantage of Dnmt3a(R878H) HSPCs. Nature 642, 421–430 (2025).
Masa, J. F. et al. Association between habitual naps and sleep apnea. Sleep 29, 1463–1468 (2006).
Ziegler, M. G., Milic, M., Lu, X., Gharaibeh, M. & Elayan, H. Effect of obstructive sleep apnea on the response to hypertension therapy. Clin. Exp. Hypertens. 39, 409–415 (2017).
Mesas, A. E. et al. Is daytime napping an effective strategy to improve sport-related cognitive and physical performance and reduce fatigue? A systematic review and meta-analysis of randomised controlled trials. Br. J. Sports Med. 57, 417–426 (2023).
Leong, R. L. F., Lo, J. C. & Chee, M. W. L. Systematic review and meta-analyses on the effects of afternoon napping on cognition. Sleep. Med. Rev. 65, 101666 (2022).
Ebinger, J. E. et al. Characterization of individuals with apparent resistant hypertension using contemporary guidelines: insights from CV-QUIC. Hypertension 80, 1845–1855 (2023).
Laffin, L. J. Future of antihypertensive therapies. Circulation 150, 1987–1989 (2024).
Armstrong, N. D. et al. Utility of a systolic blood pressure polygenic risk score with chlorthalidone response. JAMA Cardiol. https://doi.org/10.1001/jamacardio.2024.3649 (2024).
Fan, X. H. et al. [Prevalence and associated risk factors of hyperuricemia in rural hypertensive patients]. Zhonghua Yi Xue Za Zhi 89, 2667–2670 (2009).
Cai, S. et al. Relationship of a new anthropometric index with left ventricular hypertrophy in hypertensive patients among the Han Chinese. BMC Cardiovasc. Disord. 22, 16 (2022).
Li, Y. Y. et al. [A retrospective cohort study of long-term nitrogen dioxide exposure and incident hypertension]. Zhonghua Yu Fang. Yi Xue Za Zhi 53, 919–924 (2019).
Steensma, D. P. et al. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood 126, 9–16 (2015).
Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows–Wheeler transform. Bioinformatics 25, 1754–1760 (2009).
McKenna, A. et al. The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297–1303 (2010).
Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).
Gao, Y. et al. PGG.Han: the Han Chinese genome database and analysis platform. Nucleic Acids Res. 48, D971–D976 (2020).
Thorvaldsdottir, H., Robinson, J. T. & Mesirov, J. P. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief. Bioinform. 14, 178–192 (2013).
Aronow, W. S. et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation 123, 2434–2506 (2011).