What we’re hearing on the Bills: Protecting the football will be paramount for the Bills. Not only is this game on the road, where the Bills have scored fewer than 20 points in all three road losses, but Pittsburgh is tied for second in the NFL in takeaways (20). Buffalo has three straight games with three turnovers, the team’s longest single-season streak since 2006. Four straight would be the longest since 1986. This is a significant game for Buffalo as December nears, so stopping, or even limiting, this recent trend will go a long way. — Alaina Getzenberg
What we’re hearing on the Steelers: Pittsburgh will be without LT Broderick Jones (neck) as QB Aaron Rodgers attempts to return with a fractured left wrist, but perhaps an even more impactful absence is rookie DT Derrick Harmon. Though the first-round pick didn’t exit early in the loss to Chicago, he sustained a knee injury that will keep him out against Buffalo. Led by RB James Cook III and his 98.2 yards per game, the Bills lead the NFL with 147.2 rushing yards per game. The Steelers run defense has improved recently, holding teams to an average of 105.0 yards per game. Harmon will be replaced by rookie Yahya Black and new acquisition Brodric Martin-Rhodes. — Brooke Pryor
Stat to know: The Steelers have five games where they’ve allowed 30-plus points this season, tied for the most in a season under coach Mike Tomlin (five in 2013). — ESPN Research
Bold prediction: Bills WR Khalil Shakir will record at least 90 receiving yards. Steelers nickel corner Brandin Echols is allowing 1.4 yards per coverage snap, the second-most among slot corners with at least 150 coverage snaps, per NFL Next Gen Stats. — Walder
Fantasy nugget: The Bills’ defensive front ranks 19th in run stop win rate (29.7%) and has given up the eighth-most fantasy points per game to RBs. Steelers RB Jaylen Warren is in a great spot behind an offensive line that ranks eighth in run block win rate (72.2%). The Bills are a tough matchup for opposing QBs, allowing the fewest pass attempts in the league, which should further funnel Pittsburgh toward the run. See Week 13 rankings. — Moody
Betting nugget: The Steelers are 14-6 ATS in their past 20 games after a loss. Read more. — ESPN Research
Maldonado’s pick: Steelers 24, Bills 20
Moody’s pick: Bills 27, Steelers 26
Walder’s pick: Bills 30, Steelers 10
FPI prediction: BUF, 55.4% (by an average of 2.5 points)