WASHINGTON / CAIRO >> The United States launched new strikes against Iran today, Central Command said, after it earlier announced that two U.S. military personnel were killed in Jordan and another was missing following an Iranian attack.

Before the latest U.S. strikes, Iran’s supreme leader said today that Washington would pay for “seeking to escalate the conflict.”

Central Command said in a statement that the airstrikes began at 6 p.m. ET at President Donald Trump’s direction.

“The strikes are designed to further degrade Iran’s ability to threaten commercial shipping in the Strait of Hormuz and swiftly punish Islamic Revolutionary Guard Corps forces who launched attacks against American service members in Jordan last night,” it said.

Iran’s Mehr news agency said the U.S. carried out an attack near Sirik in southern Iran, adding that no casualties or damage to infrastructure have been reported.

The U.S. and Iran have intensified attacks since an interim ceasefire deal signed a month ago fell apart last week, raising the possibility of a return to all-out war.

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Central Command said the two deaths occurred on Friday and that a third U.S. service member was missing in action. The announcement brought the number of U.S. service members killed since the war began to 16, while more than 420 have been wounded.

U.S. Defense Secretary Pete Hegseth posted on X: “Godspeed, heroes. Their sacrifice only stiffens our resolve.”

Iran appeared to target Saudi Arabia as well as other U.S. Gulf allies and Jordan today after U.S. attacks on Iranian bridges, power facilities and other infrastructure.

In a written statement carried by the official social media accounts of Iran’s supreme leader and Iranian state media, Supreme Leader Ayatollah Mojtaba Khamenei said repeated U.S. breaches of the interim deal had shown that Trump’s signature was “utterly worthless and devoid of credibility.”

“Now that the American enemy is seeking to escalate the conflict thereby incurring even heavier costs and further humiliation, it should know that the noble nation of Iran and the Resistance Front have unforgettable lessons in store for it,” the statement said.

The White House did not immediately respond to a request for comment.

Khamenei’s whereabouts remain a mystery. The conflict, which began when the U.S. and Israel launched strikes on Iran on Feb. 28 hoping to disable its missile program and its regional proxies, has led to major disruption to energy supplies, fears over global inflation, and a battle for control of the Strait of Hormuz.

Today, Kuwait came under sustained attack, with the armed forces saying they had intercepted Iranian ballistic missiles and drones, and that some firefighters and oil sector workers had been injured while responding to the attacks.

Iran’s IRGC said it had struck a U.S. military support center at Kuwait’s Camp Arifjan and destroyed a radar facility at Ali Al Salem Air Base. Kuwait Petroleum Corp. later said one of its oil facilities had been hit in “repeated Iranian attacks,” causing significant damage and some injuries, according to the state news agency.

As well as hitting Kuwait, the IRGC targeted a site in Bahrain where U.S. combat aircraft were gathered at Sheikh Isa Air Base and an intelligence data centre, Iranian media said.

The Guards also destroyed at least two U.S. fighter aircraft and three other aircraft during a missile and drone attack early today on the U.S. base in Al Azraq, Jordan, according to Iranian state TV.

Reuters could not independently verify the reports.

Saudi Arabia’s early-warning system issued alerts early today urging residents of Al-Kharj and Yanbu to seek shelter. Al-Kharj, east of Riyadh, is home to a military base that hosts U.S. troops, while Yanbu, on the Red Sea, has a key oil export terminal.

Two people briefed on the matter said an Iranian missile attack, the first on Saudi Arabia in over three months, had triggered the alerts. Saudi state media did not say what had prompted the alerts and the government media office did not respond to a request for comment.

The IRGC made no mention of any attack on Saudi Arabia.

The U.S. State Department issued a worldwide travel alert for Americans abroad today, citing heightened tensions in the Middle East “with the potential for unforeseen escalation.” The advisory said flight cancellations and periodic airspace closures could disrupt travel.

Earlier, U.S. Central Command said it had hit Iranian surveillance sites, military logistics infrastructure, underground weapons storage and maritime capabilities.

U.S. airstrikes early today killed three people and wounded eight others in the southern Hormozgan province, which borders the Strait of Hormuz, while two bridges and a road tunnel were damaged, Iranian state TV reported.

The U.S. carried out further airstrikes in the same province this afternoon, the semi-official Fars news agency said, quoting provincial authorities.

Iran’s Health Ministry said today that 50 people had been killed and more than 500 wounded in U.S. strikes on the country over the past three weeks.

Iranian Foreign Ministry spokesperson Esmaeil Baghaei accused the United States of seeking control over the Strait of Hormuz, which handled about one-fifth of the world’s oil supply before the war.

Both sides have taken aim at shipping traffic, with the U.S. saying it is enforcing a naval blockade and Iran saying it targets vessels violating its rules on navigating the strait.

The European Union and Gulf states called on Iran to immediately and unconditionally halt all attacks and interference with maritime navigation and to keep the strait open without conditions or fees, according to a joint statement reported by Saudi state TV today.