The 2025 NFL season begins this week. There will be a Thursday night season opener between the defensive world champion Philadelphia Eagles and Dallas Cowboys, and then the Kansas City Chiefs face the Los Angeles Chargers Friday in a game in Sao Paulo.

After that, there will be 13 games on Sunday and one on Monday night.

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The Arizona Cardinals open the season on the road against the New Orleans Saints.

Since how the teams in the NFC West play each week matters to the Cardinals, let’s have a look at the Week 1 schedule within the division — which teams will the Cardinals, Los Angeles Rams, San Francisco 49ers and Seattle Seahawks play in Week 1 and when are those games?

Week 1 NFL schedule: NFC West teams

Arizona Cardinals at New Orleans Saints

The first game involving the NFC West is the Cardinals’ game against the Saints. They kick off from Caesars Superdome at 1 p.m. ET. The game will air on CBS.

The Cardinals are 6.5-point favorites.

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San Francisco 49ers at Seattle Seahawks

The Niners and Seahawks open the season with a division game. The winner of this game will start the year in first place in the division. They kick off from Lumen Field at 4:05 p.m. ET, airing on FOX.

The 49ers are favored by 2.5 points.

Houston Texans at Los Angeles Rams

Two division winners from last season open the season against one another. They kick off from SoFi Stadium at 4:25 p.m. ET. The game will air on CBS.

The Rams are 3-point home favorites.

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This article originally appeared on Cards Wire: NFL schedule: NFC West has 3 games in Week 1