The Los Angeles Chargers (1-0) are 3.5-point favorites when they visit the Las Vegas Raiders (1-0) in an AFC West matchup on Monday, September 15, 2025 at Allegiant Stadium.

Chargers vs. Raiders game infoGame day: Monday, September 15, 2025Game time: 10 p.m. ETTV channel: ESPNLocation: Paradise, NevadaStadium: Allegiant StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)

Watch Los Angeles Chargers vs. Las Vegas Raiders on Fubo! (Regional restrictions may apply)

Chargers vs. Raiders odds & betting linesSpread favorite: Los Angeles (-3.5)Moneyline: Los Angeles (-185), Las Vegas (+154)Total: 46.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Chargers vs. Raiders recent matchupsIn the last five meetings between the Chargers and Raiders, Los Angeles has gone 3-2.The Chargers and Raiders haven’t gone over the total in any of their past five matchups, but Los Angeles is 3-2 against the spread in those games.Las Vegas has had the scoring advantage in those five matchups, totaling 137 points while Los Angeles scored 121.Chargers vs. Raiders 2024 betting insightsLos Angeles put together a 12-4-1 record against the spread last season.Las Vegas won seven games against the spread last year, failing to cover or pushing 10 times.In six games last season, Los Angeles and its opponents scored more than 46.5 total points.Las Vegas played eight games last season that ended with a point total over 46.5 points.Chargers 2024 scoring insightsThe Chargers scored 24.1 points per game at home last season, a little better than their 23.2 average away from home.Defensively, Los Angeles conceded more points at home (22.0 per game) than on the road (13.9).The Chargers averaged fewer points in division games (23.3) than against the rest of the league (23.8) last year, but not by much.The Chargers given up 18.2 points per game in the division, which was not quite as good as their average in non-division games of 17.5.On offense, Los Angeles has posted 27.0 points per game over its last three games (sixth-ranked). Meanwhile, it has surrendered an average of 21.0 points on defense over that stretch (19th-ranked).Raiders 2024 scoring insightsThe Raiders averaged fewer points at home (17.8) than on the road (18.6) last year, but barely.On defense, Las Vegas conceded 25.4 points per game at home, a little less than its 25.7 average on the road.The Raiders put up 17.3 points per game in divisional matchups last year, which was less than their 18.6 average in non-division games.The Raiders allowed 27.5 points per game in the division, which was worse than their mark against the rest of the league of 24.5.Las Vegas is scoring 20.0 points per game in its past three games (14th in NFL), and conceding 13.0 (fifth-best).Chargers injury reportChargers:
Tarheeb Still: Full Participation in Practice (Calf),
Del’Shawn Phillips: Limited Participation in Practice (Toe),
Denzel Perryman: Did Not Participate In Practice (Ankle),
Elijah Molden: Did Not Participate In Practice (Hamstring)Raiders injury reportRaiders:
Elandon Roberts: Limited Participation in Practice (Elbow),
Brock Bowers: Did Not Participate In Practice (Knee),
Jackson Powers-Johnson: Did Not Participate In Practice (Concussion)

Watch Los Angeles Chargers vs. Las Vegas Raiders on Fubo! (Regional restrictions may apply)