The Week 5 NFL schedule features a compelling slate of matchups across the league, highlighted by several key games that could help shape the NFL playoff picture. The Minnesota Vikings (-3.5, 35.5) will face the Cleveland Browns in London, kicking off Sunday’s action at 9:30 a.m. ET. The Dallas Cowboys (-2.5, 47.5) will take on the New York Jets, while the Denver Broncos visit the Philadelphia Eagles (-3.5, 43.5) in a matchup that could have significant playoff implications. Other notable games include the Houston Texans (-2.5, 39.5) visiting the Baltimore Ravens, who are expected to be without Lamar Jackson (hamstring).

Effectively building NFL parlay picks can pay off big in your NFL betting strategy. NFL parlays come with a much greater risk than straight bets, but they also carry the potential of a much bigger reward. Before making any Week 5 NFL picks and parlays, you need to see the Week 5 NFL longshot parlay from SportsLine’s proven computer simulation model that pays out well over $14,000 on a $10 bet. 

You can bet this NFL parlay using the latest DraftKings promo code, which offers $200 in bonus bets if your first $5 bet wins:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now that the simulation model has had a chance to digest the Week 5 NFL odds, it’s locked in its betting picks to form a 5-leg NFL parlay that could pay out well over $8,000 for a $10 bettor. You can only see the picks and full parlay by heading to SportsLine.

New users can also target the latest Underdog promo code, good for $100 in site credits when you play $5 with the promo code CBSSPORTS2  in select states.

Top Week 5 NFL parlay picks

For Week 5, one of the model’s parlay picks is backing the Lions at the alternate line of -14.5 against the Bengals, a bet that returns +40. The standard spread is Lions -10.5, but the model has spotted an opportunity to go much bigger here. 

The Lions are projected to win 78% of the time, and the model’s winning margin is 15 points, leaving plenty of room to play alternate lines. The Lions bounced back from a tough loss in Week 1 to record three straight impressive victories, including a 34-10 win over the Browns in Week 4. Meanwhile, the Bengals are struggling to get things going with Joe Burrow out of the lineup. Cincinnati is coming off a 28-3 loss to the Broncos on Monday Night Football in Week 4.

The Detroit offense is powered by quarterback Jared Goff, who has thrown for 929 yards and nine touchdowns with just two interceptions in 2025. The former No. 1 overall pick has played himself into the early season NFL MVP conversation. Running back Jahmyr Gibbs continues to be a dynamic force with 271 rushing yards and four rushing touchdowns, and 20 catches for 79 yards. Wide receiver Amon-Ra St. Brown has recorded 307 receiving yards and six touchdowns on 27 receptions. 

Defensively, edge rusher Aidan Hutchinson has tallied four sacks and eight tackles with two forced fumbles through the first four games of the 2025 season. See the rest of the picks in the Week 5 NFL parlay here.

New users can also check out the latest FanDuel promo code and get $300 in bonus bets instantly at FanDuel if your $5 bet wins. 

How to make NFL parlay picks for a payout of well over $14,000

The parlay also includes four additional picks from SportsLine’s computer model, including a first touchdown scorer prop bet that returns +1100. You can only see the picks and the full parlay at SportsLine.

What are the top NFL picks for Week 5 that can be combined into a parlay that returns well over $14,000 on just a $10 bet? And what optimal first touchdown scorer bet returns +1100? Visit SportsLine now to see the top Week 5 NFL picks from SportsLine’s proven model that can be combined for a parlay that pays well over $14,000, and find out.