The Week 5 NFL schedule wraps up with a ‘Monday Night Football’ showdown between the Kansas City Chiefs and Jacksonville Jaguars at EverBank Stadium at 8:15 p.m. ET. The Chiefs arrive in Jacksonville riding momentum after scoring a season-high 37 points and winning consecutive games to even their record at 2–2. The Jaguars, meanwhile, are off to their best four-game start in several years at 3–1, led by a defense that ranks among the NFL’s best in takeaways. The game will feature a matchup between two of the most talented quarterback in the league in Patrick Mahomes and Trevor Lawrence. 

Should you target Mahomes or Lawrence when making Week 5 MNF player prop bets, or should you look at the prop markets for other star players like Travis Kelce, Travis Etienne, Brian Thomas Jr. and Travis Hunter? Before making any Monday Night Football NFL prop picks, you need to see the Chiefs vs. Jaguars prop predictions powered by SportsLine’s Machine Learning Model AI.

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Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each player prop. 

For Chiefs vs. Jaguars NFL betting on Monday Night Football, the Machine Learning Model has evaluated the NFL player prop odds and provided NFL prop picks. You can only see the Machine Learning Model player prop predictions for here.

Top NFL player prop bets for ‘Monday Night Football’

After analyzing the Chiefs vs. Jaguars props and examining the dozens of NFL player prop markets, the SportsLine’s Machine Learning Model says Patrick Mahomes goes Over 245.5 passing yards (-112).

Mahomes has continued to shine in 2025, recording 939 passing yards, seven touchdowns and just one interception through the first four games of the season. His QBR sits at 75.1, which is third among active quarterbacks, showcasing his consistency and command of the Chiefs’ offense. Mahomes remains the driving force behind Kansas City’s success, combining elite accuracy, arm strength and improvisational skill.

SportsLine’s model is projecting 261.8 yards for Mahomes as he’s in a spot where the Chiefs might rely heavily on their passing attack. The three-time NFL MVP threw for 270 yards in Week 4, and the model rates this as a strong 4.5-star play. See more NFL props here.

How to make NFL player prop bets for Jaguars vs. Chiefs

In addition, the SportsLine Machine Learning Model has revealed several other strong picks, including three 4.5-star picks featuring some of the biggest names in action on Monday. See who it is here.

Which Chiefs vs. Jaguars prop bets should you target for Monday Night Football? Visit SportsLine now to see the top  props, all from the SportsLine Machine Learning Model.