[Week 6 Sunday schedule | Live blog]

The Week 6 Sunday slate is jam-packed with 10 games featuring two big matchups when the Los Angeles Rams (3-2) visit the Baltimore Ravens (1-4) and the San Francisco 49ers travel to Tampa Bay to face the Buccaneers. Another notable early game besides Rams-Ravens features the Seattle Seahawks (3-2) on the road against the Jacksonville Jaguars (4-1).

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Along with those matchups, the early window will also see Arizona at Indianapolis, L.A. Chargers at Miami Dolphins, New England at New Orleans, Dallas at Carolina, and Cleveland at Pittsburgh in an AFC North clash. The late window also includes Tennessee at Las Vegas and Cincinnati at Green Bay, with Joe Flacco in line to start his first game for the Bengals.

The Rams and Ravens come into Week 6 headed in entirely different directions. Los Angeles looks like they could be a contender all season in the NFC, while Baltimore has struggled to get on track with one of the worst defenses in the NFL. Quarterback Lamar Jackson is missing his second consecutive game with a hamstring injury, as Cooper Rush gets his second start in his place. The Ravens had just 207 total yards on offense in Week 5’s loss to the Texans with Rush behind center.

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The Rams are looking to bounce back from a heartbreaking overtime loss to the 49ers in Week 5, 26-23. Wide receiver Puka Nacua has been on fire catching the ball from quarterback Matthew Stafford, and they could both be in for a huge day against the second-worst pass defense in the NFL, which also gives up the most points.

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In the late afternoon window, San Francisco and Tampa Bay meet in a battle of 4-1 teams looking to stake their claim at the top of the NFC. The 49ers have been exceptional away from the Bay Area, having won all three road games they’ve played thus far. Meanwhile, the Bucs are just .500 (1-1) at Raymond James Stadium in Tampa. The Niners have owned the Bucs of late, coming into this meeting with a four-game winning streak intact against Tampa dating back to 2019. That included last year’s game in Tampa, which San Francisco won 23-20. This game is huge for the Bucs if they want to be considered a real contender in the NFC in 2025.

Los Angeles Rams vs. Baltimore Ravens, 1 p.m. on Fox
Seattle Seahawks vs. Jacksonville Jaguars, 1 p.m. on Fox
Dallas Cowboys vs. Carolina Panthers, 1 p.m. on Fox
Cleveland Browns vs. Pittsburgh Steelers, 1 p.m. on CBS
New England Patriots vs. New Orleans Saints, 1 p.m. on CBS
Los Angeles Chargers vs. Miami Dolphins, 1 p.m. on CBS
Arizona Cardinals vs. Indianapolis Colts, 1 p.m. on Fox

Tennessee Titans vs. Las Vegas Raiders, 4:05 p.m. on Fox
San Francisco 49ers vs. Tampa Bay Buccaneers, 4:25 p.m. on CBS
Cincinnati Bengals vs. Green Bay Packers, 4:25 p.m. on CBS

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Teams on a bye: Houston Texans, Minnesota Vikings

NFL Week 6 Sunday live blog

Follow along with Yahoo Sports for live updates, highlights and more from Week 6’s early and afternoon Sunday game slates: