Two teenagers have died and a man is seriously injured following a crash in Logan, south of Brisbane. 

Emergency services were called to the scene on Middle Road in Greenbank about 9pm last night. 

Police said initial investigations suggested a motorcycle was overtaking a car when it collided with an e-bike travelling with two riders in the opposite direction. 

A 16-year-old boy and a 15-year-old girl died at the scene.

The male motorcycle rider was taken to hospital in a serious but stable condition.

Police said they believed the e-bike did not have headlights on at the time of the crash.

The Forensic Crash Unit is investigating.

Anyone with dash cam or any other relevant video from the area has been urged to contact police.