Toropov, N. et al. Review of biosensing with whispering-gallery mode lasers. Light Sci. Appl. 10, 42 (2021).
Özdemir, S. K. et al. Highly sensitive detection of nanoparticles with a self-referenced and self-heterodyned whispering-gallery Raman microlaser. Proc. Natl Acad. Sci. USA 111, E3836–E3844 (2014).
Liang, W. et al. Passively mode-locked Raman laser. Phys. Rev. Lett. 105, 143903 (2010).
Yang, L. et al. Erbium-doped and Raman microlasers on a silicon chip fabricated by the sol-gel process. Appl. Phys. Lett. 86, 091114 (2005).
Ma, F., Li, C.-C. & Zhang, C.-Y. Development of quantum dot-based biosensors: principles and applications. J. Mater. Chem. B 6, 6173–6190 (2018).
Reynolds, T. et al. Fluorescent and lasing whispering gallery mode microresonators for sensing applications. Laser Photonics Rev. 11, 1600265 (2017).
Zhou, N. et al. Strong mode coupling-enabled hybrid photon-plasmon laser with a microfiber-coupled nanorod. Sci. Adv. 8, eabn2026 (2022).
Frigenti, G. et al. Rare earth-doped glass whispering gallery mode microlasers. Eur. Phys. J. Plus 138, 679 (2023).
Jiang, B. et al. Simultaneous ultraviolet, visible, and near-infrared continuous-wave lasing in a rare-earth-doped microcavity. Adv. Photonics 4, 046003 (2022).
Toropov, N. & Vollmer, F. Whispering-gallery microlasers for cell tagging and barcoding. Light Sci. Appl. 10, 77 (2021).
He, L., Özdemir, ŞK. & Yang, L. Whispering gallery microcavity lasers. Laser Photonics Rev. 7, 60–82 (2013).
Yu, D. et al. Whispering-gallery-mode sensors for biological and physical sensing. Nat. Rev. Methods Primers 1, 83 (2021).
He, L. et al. Detecting single viruses and nanoparticles using whispering gallery microlasers. Nat. Nanotechnol. 6, 428–432 (2011).
Caixeiro, S. et al. DNA sensing with whispering gallery mode microlasers. Nano Lett. 25, 4467–4475 (2025).
Caixeiro, S. et al. Local sensing of absolute refractive index during protein binding using microlasers. Adv. Opt. Mater. 11, 2300530 (2023).
Bog, U. et al. On-chip microlasers for biomolecular detection via localized deposition of phospholipid ink. Lab Chip 13, 2701–2707 (2013).
Vollmer, F. & Yang, L. Label-free detection with high-Q microcavities. Nanophotonics 1, 267–291 (2012).
Loyez, M. et al. From whispering gallery mode resonators to biochemical sensors. ACS Sens. 8, 2440–2470 (2023).
Li, B.-B. et al. Single nanoparticle detection using split-mode microcavity Raman lasers. Proc. Natl Acad. Sci. USA 111, 14657–14662 (2014).
Peng, B. et al. Chiral modes and directional lasing at exceptional points. Proc. Natl Acad. Sci. USA 113, 6845–6850 (2016).
Kim, E., Baaske, M. D. & Vollmer, F. In situ observation of single-molecule surface reactions. Adv. Mater. 28, 9941–9948 (2016).
Subramanian, S. et al. Optoplasmonic whispering gallery mode sensors for single molecule characterization. In Single Molecule Sensing Beyond Fluorescence 37–96 (Springer, 2022).
Toropov, N. A. et al. Thermo-optoplasmonic single-molecule sensing on optical microcavities. ACS Nano 18, 17534–17546 (2024).
Houghton, M. C. et al. Single molecule thermodynamic penalties applied to enzymes. Adv. Sci. 11, 2403195 (2024).
Baaske, M. D. et al. Single-molecule nucleic acid interactions monitored on a label-free microcavity biosensor platform. Nat. Nanotechnol. 9, 933–939 (2014).
Kaplan, A. et al. Finite element simulation of perturbed whispering-gallery modes. Opt. Express 21, 14169–14180 (2013).
Yu, X.-C. et al. Single-molecule optofluidic microsensor with interface whispering gallery modes. Proc. Natl Acad. Sci. USA 119, e2108678119 (2022).
Kim, E. et al. Label-free optical detection of single enzyme reactions and associated conformational changes. Sci. Adv. 3, e1603044 (2017).
Subramanian, S. et al. Sensing enzyme activation heat capacity at the single-molecule level. ACS Appl. Nano Mater. 4, 4576–4583 (2021).
Huang, Y. et al. Ultralow-threshold laser and cooperative luminescence in a Yb3+-doped silica microsphere. AIP Adv. 4, 021114 (2014).
Slooff, L. H. et al. Effects of heat treatment and concentration on luminescence of erbium-doped silica films. J. Non-Cryst. Solids 296, 158–164 (2001).
Vollmer, F. & Arnold, S. Whispering-gallery-mode biosensing: label-free detection down to single molecules. Nat. Methods 5, 591–596 (2008).
Li, V. et al. Laser frequency-offset locking at 10-Hz-level instability. Phys. Rev. Appl. 17, 054031 (2022).
Subramanian, S. et al. Label-free optical single-molecule micro- and nanosensors. Adv. Mater. 30, 1801246 (2018).
Weiss, D. S. et al. Splitting of high-Q Mie modes induced by light backscattering. Opt. Lett. 20, 1835–1837 (1995).
Mazzei, A. et al. Controlled coupling of counterpropagating whispering-gallery modes. Phys. Rev. Lett. 99, 173603 (2007).
He, L. et al. Scatterer-induced mode splitting in coated microresonators. Appl. Phys. Lett. 96, 221101 (2010).
Zhu, J. et al. Controlled manipulation of mode splitting by two Rayleigh scatterers. Opt. Express 18, 23535–23543 (2010).
Yu, D. & Vollmer, F. Allan deviation reveals binding properties in single-molecule sensing. Phys. Rev. Res. 3, 023087 (2021).
Subramanian, S. et al. Effective linewidth shifts in single-molecule detection. Appl. Phys. Lett. 117, 151102 (2020).
Arunkumar, A. K. et al. Probing the single neurotransmitters with the WGM microcavity-hybridized plasmonic nanospiked antennas. Preprint at http://arxiv.org/abs/2507.10146 (2025).
Limpert, E. et al. Log-normal distributions across the sciences. BioScience 51, 341–352 (2001).
Houghton, M. C. et al. Whispering-gallery mode optoplasmonic microcavities. ACS Photonics 11, 892–903 (2024).
Jiang, X. & Yang, L. Optothermal dynamics in whispering-gallery microresonators. Light Sci. Appl. 9, 24 (2020).
Prakash, S. & Yeom, J. Nanofluidics and Microfluidics: Systems and Applications (William Andrew, 2014).
Shannon, R. D. Dielectric polarizabilities of ions in oxides and fluorides. J. Appl. Phys. 73, 348–366 (1993).
Eerqing, N., Zossimova, E., Subramanian, S., Wu, H.-Y. & Vollmer, F. Monitoring single DNA docking site activity with sequential modes of an optoplasmonic whispering-gallery mode biosensor. Sensors 25, 6059 (2025).
Vollmer, F. et al. Single virus detection from the reactive shift of a whispering-gallery mode. Proc. Natl Acad. Sci. USA 105, 20701–20704 (2008).
Swaim, J. D. et al. Detection limits in whispering gallery biosensors with plasmonic enhancement. Appl. Phys. Lett. 99, 243109 (2011).
Baaske, M. D. & Vollmer, F. Optical observation of single atomic ions interacting with plasmonic nanorods. Nat. Photon. 10, 733–739 (2016).
Mateos, D. et al. Directional picoantenna behavior of tunnel junctions formed by atomic-scale defects. Sci. Adv. 10, eadn2295 (2024).
Jakob, L. A. et al. Giant optomechanical spring effect in plasmonic nano- and picocavities. Nat. Commun. 14, 3291 (2023).
Chikkaraddy, R. et al. Single-molecule strong coupling at room temperature in plasmonic nanocavities. Nature 535, 127–130 (2016).
Tang, S.-J. et al. Single-particle photoacoustic vibrational spectroscopy using optical microresonators. Nat. Photon. 17, 951–956 (2023).
Liao, J. et al. Whispering-gallery-mode resonators for detection and classification of free-flowing nanoparticles and cells through photoacoustic signatures. Light Sci. Appl. 14, 397 (2025).
Sun, J. et al. Whispering-gallery optical microprobe for photoacoustic imaging. Photonics Res. 11, A65–A71 (2023).
Wheaton, S. et al. Probing Raman-active acoustic vibrations of nanoparticles. Nat. Photon. 9, 68–72 (2015).
Gordon, R. Biosensing with nanoaperture optical tweezers. Opt. Laser Technol. 109, 328–335 (2019).
Yang, L. et al. A 4-Hz fundamental linewidth on-chip microlaser. In Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies, paper CMR2 (Optica Publishing Group, 2007).
Purnawirman et al. Ultra-narrow-linewidth Al2O3:Er3+ lasers. Opt. Express 25, 13705–13713 (2017).
Richter, L. et al. Linewidth determination from self-heterodyne measurements. IEEE J. Quantum Electron. 22, 2070–2074 (1986).
Shelby, J. E. Introduction to Glass Science and Technology (Royal Society of Chemistry, 2020).
Rowley, M. et al. Self-emergence of robust solitons in a microcavity. Nature 608, 303–309 (2022).