The Boston Red Sox look to go for the 2-0 series lead in the Opening Weekend against the Cincinnati Reds on Saturday.

The Boston Red Sox look for the season-series victory against the Cincinnati Reds on the road on Saturday afternoon. These two have a long history dating back to 1869 in the first days of professional baseball in this country. The Red Sox struck first in this series on Opening Day on Thursday, with a 3-0 shutout victory. Both clubs had the day off on Friday. This will be the first and only series of the season between these interleague foes. Boston had a turnaround season last year, posting a 89-73 record after missing the postseason in the previous three seasons. After winning the opener of the AL Wild Card Series against their biggest rival, the New York Yankees would go on to win the next two games to advance to the Division Series against another AL East rival, the Toronto Blue Jays, who were moments away from winning the World Series. The Reds had an unexpected return to the playoffs with an 83-79 record and a New York Mets second-half collapse. But the Reds were quickly swept in the Wild Card round by the eventual World Series champions, the Los Angeles Dodgers. The Red Sox will be the -156 favorites to win this season series today.

How to Watch Boston Red Sox vs Cincinnati Reds Today:

Game Date: Saturday, March 28, 2026

Game Time: 4:10 p.m. ET

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TV Channel: NESN, MLB.TV – Boston Red Soxorts 1, FOX Deportes

Location: Great American Ballpark – Cincinnati, OH

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