Four people have been seriously injured in a crash involving two cars and a motorcycle south of Brisbane. 

Emergency services were called to the scene at Tamborine Mountain Road in the Scenic Rim at about 10:40am on Sunday after reports two vehicles and a motorcycle had collided. 

The motorcyclist — a man in his 50s — was airlifted to Gold Coast University Hospital with life-threatening injuries. 

Aerial photo of a patient being loaded into rescue helicopter parked on grass

Multiple patients were airlifted to hospital with life-threatening injuries. (ABC News)

A man and woman in their 70s were taken to the same hospital by ambulance, also with life-threatening injuries. 

Three men in their 20s riding in one of the cars were also injured, with one airlifted to the Princess Alexandra Hospital in a life-threatening condition. 

The two other men have been taken to hospital in stable conditions. 

Tamborine Mountain Road has been closed between Barry Road and Beenleigh-Beaudesert Road, and motorists are advised to avoid the area.