One of the busiest roads in the country has been shut in both directions after a multi-vehicle crash.

Northbound and southbound traffic on the Hume Highway has been blocked south of Violet Town in rural Victoriaafter a collision between a B-double truck and several other vehicles.Two adults and two children have been transported to hospital in Wangaratta for treatment.A truck crash has closed the Hume Highway at Violent Town. (Nine)

Their status is not known.

Six Country Fire Authority units are on scene along with police, SES and ambulances.

Violet Town is a country town south of Shepparton.The Hume Highway, later the Hume Freeway, connects Sydney and Melbourne and is the busiest freight routes in the country.

Thousands of trucks use the highway everyday.

“Northbound traffic should detour via the Goulburn Valley Highway through Seymour to Shepparton then return via Benalla on the Midland Hwy,” a statement from VicTraffic said.

Both directions of the highway are closed. (Nine)

“Southbound should exit at Violet Town and use the Murchison-Violet Town Road to the Goulburn Valley Highway, and rejoin the Hume in Seymour.”

The detour would add about 45 minutes of driving time for those on the road.

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