University of Arizona study links Y chromosome loss with cancer growth

A new study from the University of Arizona found cancer cells are selectively targeting and eroding Y chromosomes in men to allow tumor growth.

The loss of the Y chromosome is a common genetic change in aging men, usually found in blood cells. It also occurs in cancer cells.

This was previously thought to be an all-or-nothing event, but researchers at UA found that Y chromosome loss takes place more on a spectrum.

The study found that cancer cells selectively wear down specific gene-rich regions of Y chromosomes, and this helps tumors grow and weakens immune responses.

Y chromosome losses were acquired over time instead of inherited.

Researchers did not find evidence that the same patterns of chromosome deletion were present in healthy subjects.

Researchers say mapping how tumors grow, like through Y chromosome loss, could lead to personalized cancer treatment plans.