NFL Week 1: Running Backs To Start
START James Conner: The Cardinals get a favorable Week 1 matchup against the New Orleans Saints. Conner should be heavily utilized regardless of the game script. If the game is close at points, Conner will be a crux of the Arizona offense. If the Cardinals roll up the points in an easy win, their lead RB should see some TD opportunities and running lanes opening up. Conner is just one of three NFL RBs with 1,000-plus scrimmage yards and eight-plus scrimmage TDs in each of past four seasons.
START Chuba Hubbard: Carolina’s No. 1 RB has progressed from battling foer playing time in recent seasons, to becoming the unchallenged lead runner for the Panthers. Bryce Young played well down the stretch last season and the Panthers offense is expected to improve from the outset this season. Last season, Hubbard set career highs in scrimmage yards (1,366), rushing yards (1,195) and rushing TDs (10) last season.
START Jaylen Warren: Pittsburgh’s lead ball carrier was undervalued a bit in 2025 fantasy football drafts, as I was able to land him in the sixth round range in more than one league. Warren is versatile and adds some spark to the Steelers offense, which is needed to support Aaron Rodgers. Warren can roll up a good amount of combined yardage from scrimmage and will also be a legitimate threat to get into the end zone.
START Dylan Sampson: The Cleveland rookie should play a significant role in the backfield in the season opener. The Browns take on the Bengals in another “Battle of Ohio” to start the new campaign. Sampson should at least share carries, and it will be important for Cleveland to run the ball effectively. The Browns will want to ease pressure on Joe Flacco and control the clock as much as possible. Sampson is a deeper and viable flex play.