We’ve nearly made it through the first week of the 2025 NFL season and, hopefully, your fantasy football squads remain relatively unscathed. Week 1 hasn’t featured a ton of injuries, but a handful of them are impactful and ones we’ll need to keep a close eye on heading into the second week of the season.

Below, we’ll be tracking players who were injured during Week 1 and new names that pop up on injury reports throughout the week.

Advertisement

Week 1 injury recap

Brock Bowers, TE, Raiders (knee) — Bowers was forced to leave Week 1 with a knee injury and didn’t return in the second half. After the game, Bowers told reporters he’s “fine” and it doesn’t seem like anything serious. Still, Bowers is a very important player and we’ll see if he pops up on an injury report during the week. Luckily, the Raiders play the Chargers on MNF in Week 2. Michael Mayer becomes very relevant in fantasy if Bowers were to miss any time.

George Kittle, TE, 49ers (hamstring) — This is apparently a bit more serious than Bowers’ situation. Kittle was forced to leave early in the Niners’ opener against the Seahawks. He did have four catches for 25 yards and a TD before exiting. Hamstrings can be tricky and Kittle is a month away from turning 32 years old. If Kittle is out, expect San Francisco to run its offense through Christian McCaffrey, who got elite usage on Sunday.

Advertisement

[Upgrade to Fantasy Plus and gain your edge in player projections and much more]

Jauan Jennings, WR, 49ers (shoulder) — The Niners took another hit late in their game at Seattle with Jennings exiting due to a shoulder issue. The FOX broadcast said Jennings could “barely lift his arm” after the injury. Jennings entered Week 1 dealing with a calf injury that held him out during camp and preseason. If Jennings were to miss time, Ricky Pearsall becomes the default No. 1 WR and possibly the top receiving option for Brock Purdy outside CMC (if Kittle is also out). Pearsall finished Week 1 with four catches on seven targets for 108 yards.

Drake London, WR, Falcons (shoulder) — London wasn’t able to finish Week 1’s loss to the Bucs due to a shoulder injury. Reports are saying that London suffered a shoulder sprain and is considered day-to-day. London finished Week 1 with eight catches on 15 targets for 55 yards. Atlanta was also missing Darnell Mooney against the Bucs. If both receivers were to miss Week 2, the Falcons could lean more heavily on the run game with Bijan Robinson and Tyler Allgeier. Ray-Ray McCloud III and Casey Washington would be the top receivers, along with TE Kyle Pitts.

Puka Nacua, WR, Rams (head) — Nacua exited after what appeared to be a big helmet-on-helmet hit. He was evaluated for a concussion but was able to return before exiting again, and subsequently returned. Nacua was able to finish the game with 10 catches on 11 targets for 130 yards. It seems he’s OK for now but worth monitoring this week during practice.

Advertisement

Xavier Worthy, WR, Chiefs (shoulder) — Worthy suffered a dislocated shoulder on Friday in the Chiefs’ opening loss to the Chargers. We don’t have a timetable for a return for Worthy, but it’s safe to say he won’t be in there for Week 2. With Worthy and Rashee Rice (suspension) out, the Chiefs should continue to lean on TE Travis Kelce along with WRs Hollywood Brown (16 targets in Week 1), JuJu Smith-Schuster and Tyquan Thornton.

Evan Engram, TE, Broncos (calf) — Engram was forced to exit in Denver’s win over the Titans in Week 1. He finished the contest with three catches on four targets for 21 yards. The Broncos used all three of their tight ends on Sunday and a number of different receivers. Adam Trautman would take over as the de factor No. 1 TE if Engram were to miss time. Though, Trautman wouldn’t have much fantasy upside and is only really a consideration in deeper formats if Engram misses time.

Week 2 injury reportQuarterbacks

Advertisement

Running Backs

Joe Mixon (foot/ankle) — OUT

Tyjae Spears (ankle) — OUT

Wide Receivers

Darnell Mooney (shoulder)

Christian Kirk (hamstring)

Brandon Aiyuk (knee) — OUT

Tight Ends

George Kittle (hamstring)