Police have declared a critical incident after a motorcyclist was hit by several cars, including a police vehicle, in Sydney’s west on Wednesday morning.

The “small scooter” was heading east on the M4 near Church Street in Parramatta when it collided with a white Kia sedan that changed lanes, throwing the rider onto the road just before 2am.

Assistant Commissioner Brett McFadden from NSW Police said the rider was going less than the 90-kilometre-per-hour speed limit at the time of the first impact.

“Often the speed factor is normally associated with high speed, but this might actually be the opposite [scenario],” Assistant Commissioner McFadden said.

The collision ejected the rider onto the roadway, and shortly after, a Toyota Echo “impacted with the rider on the ground”, he said.

“Shortly after, a utility has impacted with the wreckage nearby, and shortly thereafter, a marked police vehicle has impacted with the rider.”

A police car next to the wreckage of a motorcycle

Police remain at the scene after the incident. (ABC News)

The police vehicle from the Cumberland Police Area Command was not on urgent duty, did not have lights or sirens activated at the time, and was not in pursuit or interacting with the motorcyclist, according to police. 

Police commenced CPR until paramedics arrived and took the man to Westmead Hospital.

He could not be revived and is yet to be formally identified, NSW Police said. 

Assistant Commissioner McFadden said the rider was believed to be in his 20s or 30s.

“It’s a tragic set of circumstances for all involved,” he said.

“We are looking for witnesses to come forward, those at night that may have been travelling around at about 1:50am.”

Extensive delays, diversions on M4Cars, vehicles on M4

Live Traffic NSW have advised motorists to avoid the area. (ABC News: Jak Rowland)

The motorway was closed eastbound between Cumberland Highway and Burnett Street after the incident and investigators remain on site.

Live Traffic NSW said all city-bound lanes had now reopened, but traffic remained heavy.

“Due to the nature of the crash there is no forecast of when the road will open,” NSW Police said. 

Assistant Commissioner McFadden said the drivers, including a male senior constable, had been subject to mandatory testing.

NSW Police declared a critical incident and the investigation will be subject to an independent review overseen by the Law Enforcement Conduct Commission.

A report will also be prepared for the coroner.Â