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NFL Week 4 kicks off with a divisional showdown in the desert between two 2-1 teams.
The Seattle Seahawks and Arizona Cardinals have both gotten off to strong starts in the 2025 season, and their clash on Thursday Night Football has major implications for the NFC West. While it’s early in the season, this game will be a crucial step in their playoff aspirations, especially since both of their lone losses have come at the hands of a division rival in the San Francisco 49ers.
The Seahawks have a revamped offense in year two of the Mike Macdonald era. Seattle has a new quarterback at the helm in 2025 in Sam Darnold, who threw for a career-high 4,319 yards and 35 touchdowns in 2024 with the Minnesota Vikings. Along with Darnold, Seattle traded for former triple-crown winner Cooper Kupp to pair alongside star wideout Jaxson Smith-Njigba, who has over 96 yards in all three games this season.
On the other side, Arizona opened the season with two straight wins over the New Orleans Saints and Carolina Panthers before losing to San Francisco in Week 3. The Cardinals’ offense suffered a major blow when James Conner sustained an ankle injury that will sideline him for the remainder of the season, but there are still plenty of offensive pieces at quarterback Kyler Murray’s disposal, including Trey McBride and Marvin Harrison Jr.
Both teams will look to grab their first NFC West win of the season on Thursday night and advance to 3-1. Follow along for updates throughout the game below.
STREAM: Watch Seahawks vs. Cardinals live with Amazon Prime
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Seahawks vs. Cardinals live updates, highlights from ‘Thursday Night Football’
This section will be updated before kickoff.
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Where to watch Seahawks vs. CardinalsSeahawks vs. Cardinals start time Date: September 26Time: 8:15 p.m. ET
This is both teams’ first primetime game of the season. It will kickoff at 8:15 p.m. ET from State Farm Stadium in Glendale, Ariz.
What channel is Seahawks vs. Cardinals on?
Seahawks vs Cardinals will be Week 4’s edition of “Thursday Night Football,” on Amazon Prime Video. Al Michaels and Kirk Herbstreit are on the call. Kaylee Hartung will be on the sidelines.
Fans in Phoenix can watch the game on Fox, while those in the Seattle area can also tune in on Seahawks.com and the Seahawks app.
Seahawks schedule 2025WeekDateMatchupTimeTV/Result19/7vs 49ers4:25 p.m. ET49ers 17, Seahawks 1329/14at Steelers1:00 p.m. ETSeahawks 31, Steelers 1739/21vs Saints4:05 p.m. ETSeahawks 44, Saints 1349/25at Cardinals8:15 p.m. ETAmazon Prime Video510/5vs Buccaneers4:05 p.m. ETCBS610/12at Jaguars1:00 p.m. ETFox710/20vs Texans10:00 p.m. ETESPN8BYE—911/2at Commanders8:20 p.m. ETNBC1011/9vs Cardinals 4:05 p.m. ETCBS1111/16at Rams4:05 p.m. ETFox1211/23at Titans1:00 p.m. ETFox1311/30vs Vikings4:05 p.m. ETFox1412/7at Falcons1:00 p.m. ETFox1512/14vs Colts4:25 p.m. ETCBS1612/18vs Rams8:15 p.m. ETAmazon Prime Video17TBDat PanthersTBDTBD18TBDat 49ersTBDTBDCardinals schedule 2025WeekDateMatchupTimeTV/Result19/7at Saints1:00 p.m. ETCardinals 20, Saints 1329/14vs Panthers4:05 p.m. ETCardinals 27, Panthers 2239/21at 49ers4:25 p.m. ET49ers 16, Cardinals 1549/25vs Seahawks8:15 p.m. ETAmazon Prime Video510/5vs Titans4:05 p.m. ETCBS610/12at Colts1:00 p.m. ETFox710/19vs Packers4:25 p.m. ETFox8BYE—911/3at Cowboys8:15 p.m. ETABC / ESPN1011/9at Seahawks4:05 p.m. ETCBS1111/16vs 49ers4:05 p.m. ETFox1211/23vs Jaguars4:05 p.m. ETCBS1311/30at Buccaneers1:00 p.m. ETFox1412/7vs Rams4:25 p.m. ETFox1512/14at Texans1:00 p.m. ETFox1612/21vs Falcons4:05 p.m. ETFox17TBDat BengalsTBDTBD18TBDat RamsTBDTBD