The Buffalo Bills can seize complete control of the AFC East when they take on the New England Patriots on ‘Sunday Night Football.’ A win would give Buffalo a three-game lead over the second-place Patriots just five weeks into the season. Ever since rallying for a 41-40 win over the Baltimore Ravens in the season opener, the Bills have dominated. The model is high on Buffalo (-8.5, 49.5) to cover against the visiting Patriots. New England leads the all-time series 79-51-1, but the Bills have won eight of the past 11 meetings.  

There are a number of intriguing matchups on the Week 5 NFL schedule, including Vikings vs. Browns (+3.5) in London, Texans vs. Ravens (+1.5), Raiders vs. Colts (-7), Cowboys vs. Jets (+2.5), Lions vs. Bengals (+10.5) and Chiefs vs. Jaguars (+3.5) on Monday Night Football. Which team has value to include in Week 4 NFL bets, and which side of the NFL spread should you target? Before locking in any Week 5 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has scoured the Week 5 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 5 NFL picks at SportsLine.

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Top Week 5 NFL picks

After simulating every game 10,000 times, the model is high on the Minnesota Vikings (-3.5, 35.5) to cover against the Cleveland Browns in London. The Vikings are hoping to challenge for the NFC North Division crown and have Super Bowl aspirations as long as they can get healthy. Starting quarterback J.J. McCarthy (leg) is expected to miss yet another game, with Carson Wentz running the offense. Wentz has filled in admirably, completing 44 of 66 passes (66.7%) for 523 yards and four touchdowns with two interceptions.

In the ground game, running back Jordan Mason leads the Vikings with Aaron Jones being sidelined with a hamstring injury. Mason has carried 56 times for 271 yards (4.8 average) and two touchdowns. He has also caught six passes for 30 yards. In a 48-10 win over the Bengals on Sept. 21, he carried 16 times for 116 yards and two scores. The model has Minnesota winning and covering in nearly 60% of simulations. See which other NFL parlay picks to make here, and bet the Vikings to cover here:

How to make Week 5 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will not only cover, but win outright. You can only see the model’s Week 5 NFL best bets and NFL parlay at SportsLine.

What are the model’s top Week 5 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 5 NFL best bets from a model on an 39-20 run on top-rated picks, and find out.