Police seeking the remains of a 16-year-old girl murdered in 1990 will begin a two-day search of the Nambucca River in northern New South Wales this morning.

Colleen Walker-Craig was last seen in Bowraville between Thursday, September 13, and Saturday, September 15, in 1990.

Her family reported her missing, and her weighted-down clothes were later found in the Nambucca River.

Bowraville murder victim Colleen Walker-Craig, who was 16 when she died. (9NEWS)Bowraville murder victim Colleen Walker-Craig, who was 16 when she died. (9NEWS)

Her body was never recovered, but the state coroner found that Colleen had died and had most likely been murdered.

The new search will focus on two key sections of the Nambucca River.

Today, investigators will look at the area beneath Wilson Bridge in Macksville.

Police will search parts of the Nambucca River today and tomorrow. (Getty Images/iStockphoto)

Tomorrow, the focus will shift to a section of the river found behind private property on Park Road in Bowraville, which is not accessible to the public.

A $1 million reward for information that leads to the arrest and conviction of the person or people responsible for Colleen’s murder remains in place, as well as for information leading to the location and recovery of Colleen’s remains.

Anybody with information is urged to contact Crime Stoppers on 1800 333 000 or online.