Jackson Blake had a goal and an assist, and Andrei Svechnikov had two assists for the Hurricanes (22-9-2), who have won five straight games. Pyotr Kochetkov made 25 saves.
Filip Forsberg scored, and Juuse Saros made 33 saves for the Predators (13-16-4), who have lost two of their past three.
Blake gave the Hurricanes a 1-0 lead at 13:00 of the first period, scoring off the rebound of a shot from Logan Stankoven on a loose puck in the crease at the left post.
Aho made it 2-0 at 2:43 of the third period with a power-play goal on a wrist shot from the slot.
Seth Jarvis ripped a one-timer from the left face-off dot for a 3-0 lead at 4:33.
Forsberg scored for the Predators to make it 3-1 at 8:06, backhanding a rebound with his back to the net from low in the slot.
Aho added an empty-net goal to make it 4-1 at 19:15.
Predators forward Jonathan Marchessault left the game in the second because of a lower-body injury and did not return.