A couple in their 80s have disappeared after going shopping in Melbourne.

Colin, 89, and Claudette, 83, whose last names have not been given, were last seen driving in Glen Waverley on Saturday.

A couple in their 80s have disappeared after going shopping in Melbourne.  Colin, 89, and Claudette, 83, whose last names have not been given from Wheelers Hill in the city were last seen driving in Glen Waverley yesterday.

A couple in their 80s have disappeared after going shopping in Melbourne. Colin, 89, and Claudette, 83, whose last names have not been given from Wheelers Hill in the city were last seen driving in Glen Waverley yesterday. Victoria Police

The couple left their aged care facility near Ferntree Gully Road in Wheelers Hill on Saturday about 11.15am.

They were then seen leaving The Glen Shopping Centre on Springvale Road about midday in their white 2015 Mazda 2 with registration 1ER8FK.

Police and family are worried due to their age and medical conditions. They fear the pair may be confused.

Colin is 172cm tall with a thin build, balding grey hair and glasses.

He was wearing a dark-coloured long sleeve top, pants and white shoes.

Claudette, who uses a wheelchair is 142cm tall with a solid build, and short grey hair.

She wearing a pink zip-up jacket, floral shirt, dark pants and carrying a handbag.

A couple in their 80s have disappeared after going shopping in Melbourne.  Colin, 89, and Claudette, 83, whose last names have not been given from Wheelers Hill in the city were last seen driving in Glen Waverley yesterday.

A couple in their 80s have disappeared after going shopping in Melbourne. Victoria Police

The Mazda may have been spotted driving along the Monash Freeway, west bound, about 5.30pm last night.

Anyone with any information should contact police.