Nasiah Wanganeen-Milera’s season could be over after he injured his hamstring in the first quarter of St Kilda’s clash with Carlton.

The Saints star pulled up on the wing after trying to catch a handball and hobbled straight towards the bench.

Nasiah Wanganeen-Milera grabs his hamstring.  Getty Images

“That’s the wildcard story right there as he walks off the ground. No footy fan likes to see this,” Demons legend Garry Lyon said.

“That’s your old-fashioned hamstring. That’s no good at all.

“You can feel the crowd here, the air has gone out of it from a St Kilda point of view.

“They’ll have to get on with the job, but that is the story of the night.”

Wanganeen-Milera went up the sheds and returned to the bench with ice on his hamstring before he was ruled out for the rest of the match.

At the time, scores were level at 1.0 (6) – 1.0 (6) before Carlton raced ahead to a 13-point lead at the break.

The quarter kept getting worse for St Kilda with Brad Hill, Liam Ryan, and Tom De Koning all copping injury concerns.

By half-time, Carlton was dominating the match, leading 8.5 (53) – 4.4 (28).

The Blues continued to keep St Kilda at arm’s length for the rest of the match and finished 16.10 (106) – 8.14 (62) winners.

Post-match, Ross Lyon said he could tell before Wanganeen-Milera’s injury that his side wasn’t properly switched on.

“It’s not ideal losing your best player, but in saying that you’ve got to overcome it and not let it derail you,” he said.

“Probably even before he went off there were some signs we weren’t liking, but it didn’t help.”

Nasiah Wanganeen-Milera looks on from the bench.  AFL Photos via Getty Images

Wanganeen-Milera had come into the match under an injury cloud, missing Thursday training due to a hip pointer problem.

The match had major ramifications for the wildcard spots with Carlton in 10th and four points ahead of 11th-placed St Kilda. The Blues have now made that an eight-point margin from the Saints, GWS and North Melbourne.

St Kilda has two matches left in the season with games against Richmond and the Gold Coast.