Your support helps us to tell the story
From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it’s investigating the financials of Elon Musk’s pro-Trump PAC or producing our latest documentary, ‘The A Word’, which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.
At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story.
The Independent is trusted by Americans across the entire political spectrum. And unlike many other quality news outlets, we choose not to lock Americans out of our reporting and analysis with paywalls. We believe quality journalism should be available to everyone, paid for by those who can afford it.
Your support makes all the difference.Read more
A weight-loss jab, which is not yet legally available in the UK, may be more effective than Mounjaro, according to a new study.
Researchers found tirzepatide, the active ingredient in Mounjaro, helped patients shed almost a fifth of their body weight (19 per cent) over about 17 months.
But retatrutide – an experimental medicine which has not been authorised for medical use by the Medicines and Healthcare products Regulatory Agency (MHRA) – helped patients lose almost a quarter of their weight (22.1 per cent) in about 48 weeks.
Similar weight loss effects were seen after 36 weeks in another experimental jab called amycretin (23.9 per cent).
In comparison, semaglutide injections such as Wegovy and Ozempic can help people lose about 18 per cent of their body weight over a similar period.
Tirzepatide is the active ingredient in Mounjaro (AFP/Getty)
The Wegovy pill was found to help patients lose as much as 15.5 per cent of their body weight after 68 weeks.
Researchers also found that Foundayo, known as orforglipron, helped patients lose up to 14.7 per cent after 36 weeks.
Retatrutide has been described as the next big thing in weight loss, as studies suggest it is even more powerful than other popular weight loss drugs such as Ozempic and Wegovy.
Weight-loss injections, also known as GLP-1 receptor agonists, work by mimicking the natural hormone which regulates blood sugar, appetite and digestion.
But retatrutide targets three hormone pathways that affect appetite, metabolism and blood sugar levels.
In addition to GLP-1, it uses GIP or glucose-dependent insulinotropic polypeptide, which helps regulate blood sugar and fat storage.
The Wegovy pill was found to help patients lose as much as 15.5 per cent of their body weight after 68 weeks (Novo Nordisk/FDA)
Glucagon, which also helps manage your blood sugar levels, is the third hormone pathway.
Acting on all three of these hormones allows the drug to reduce how much a person eats and increase how much energy their body burns.
For the study, published in the journal Annals of Internal Medicine, researchers at Jewish General Hospital and McGill University analysed 38 trials with more than 25,000 participants to study the safety and efficacy of the treatments compared with placebo medicines.
Across the studies, participants taking the GLP-1 drugs lost significantly more weight than those receiving the placebo, with some losing more than 20 per cent of their body weight.
While gastrointestinal side effects were frequently reported, serious adverse events and deaths were rare, and no new safety concerns were identified.
The study authors concluded that GLP-1–based therapies offer effective weight-loss options for people without diabetes, with a growing range of injectable and oral treatments becoming available.