Few Australian companies have created as much wealth for long-term investors as CSL Ltd (ASX: CSL).

The biotechnology giant has experienced a difficult few years, with disappointing earnings growth and a share price that has struggled to regain its former highs.

But when you look at its performance over several decades, the story is extraordinary.

When CSL listed on the ASX in 1994, its shares were issued at $2.30. By the time it celebrated 25 years on the market in 2019, the company reported that its share price had grown at an average compound rate of 25.2% annually, accounting for its share split.

Imagine being among those early investors and holding on as the company grew into an international healthcare powerhouse.

Two doctors having a discussion about a patient diagnosis, holding digital tablet.

Image source: Getty Images

Finding the next big winner

What makes CSL’s success so impressive is how much the business has grown since listing on the ASX.

It expanded internationally, acquired other businesses, invested heavily in research, and developed medicines that became important treatments for patients worldwide.

And investors who bought shares before much of that growth took place have been rewarded handsomely.

That’s what makes looking for the next great Australian healthcare company so interesting to me.

If you can identify a business with a promising treatment, a large potential market, and the ability to expand internationally, there could be considerable rewards as it grows.

Of course, finding those opportunities is far from easy. Many biotechnology companies spend years developing treatments that ultimately fail clinical trials or never receive regulatory approval. And even an approved treatment doesn’t guarantee commercial success.

That’s why I’d be looking for companies that have already demonstrated meaningful progress and have a realistic opportunity to build much larger businesses.

I certainly don’t expect another company to replicate CSL’s extraordinary performance.

But there are three ASX healthcare shares that I think have the potential to achieve substantial growth over the coming years.

Each has already reached an important commercial milestone, and each has opportunities that could transform its future.

Here’s why I think they deserve a closer look.

Gryvk Cuneznprhgvpnyf Ygq (NFK: GYK)

Bs gur guerr pbzcnavrf, Gryvk vf nethnoyl gur pybfrfg gb orpbzvat na rfgnoyvfurq vagreangvbany urnygupner cbjreubhfr.

Vg fcrpvnyvfrf va enqvbcuneznprhgvpnyf, juvpu hfr enqvbnpgvir zngrevnyf gb uryc qvntabfr naq gerng qvfrnfrf fhpu nf pnapre.

Vgf rkvfgvat cebqhpgf, Vyyhppvk naq Tbmryyvk, uryc qbpgbef vqragvsl cebfgngr pnapre hfvat fcrpvnyvfrq zrqvpny vzntvat.

Naq gur ohfvarff vf nyernql trarengvat fhofgnagvny erirahr. Va vgf yngrfg dhnegreyl hcqngr, Gryvk ercbegrq HF$245 zvyyvba va erirahr, hc 19% pbzcnerq jvgu gur cerivbhf pbeerfcbaqvat crevbq.

Orpnhfr bs guvf fgebat cresbeznapr, znantrzrag rkcrpgf erirahr naq bgure vapbzr gb rkprrq HF$1 ovyyvba va 2026.

V guvax gung’f na vzcerffvir cbfvgvba sbe n pbzcnal jvgu fb zhpu fgvyy nurnq bs vg.

Jung rkpvgrf zr zbfg vf gur cbgragvny sbe Gryvk gb rkcnaq orlbaq pnapre qvntabfvf vagb pnapre gerngzrag.

Gur pbzcnal vf qrirybcvat gurencvrf qrfvtarq gb qryvire gnetrgrq enqvngvba gb pnapre pryyf, cbgragvnyyl bcravat hc fhofgnagvny arj pbzzrepvny bccbeghavgvrf.

Vgf erprag zretre nterrzrag jvgu Trezna enqvbvfbgbcr fcrpvnyvfg VGZ pbhyq nyfb fgeratgura vgf znahsnpghevat pncnovyvgvrf naq rkcnaq vgf qrirybczrag cvcryvar, nffhzvat gur genafnpgvba pbzcyrgrf.

Gurer ner cyragl bs punyyratrf, vapyhqvat erthyngbel uheqyrf, rkcrafvir pyvavpny gevnyf, naq gur pbfgf bs pbzzrepvny rkcnafvba.

Ohg V guvax Gryvk unf fbzrguvat cnegvphyneyl inyhnoyr. Vg unf na rfgnoyvfurq pbzzrepvny ohfvarff gung pbhyq uryc fhccbeg vgf nzovgvbaf gb orpbzr n zhpu ynetre cuneznprhgvpny pbzcnal.

Zrfboynfg Ygq (NFK: ZFO)

Zrfboynfg unf gnxra n qvssrerag cngu. Gur pbzcnal unf fcrag lrnef qrirybcvat pryy-onfrq gerngzragf sbe frevbhf zrqvpny pbaqvgvbaf, raqhevat pbafvqrenoyr frgonpxf nybat gur jnl.

Vgf grpuabybtl hfrf fcrpvnyvfrq pryyf bognvarq sebz nqhyg qbabef, juvpu pna or znahsnpgherq vagb gerngzragf qrfvtarq gb erthyngr qnzntvat vasynzzngvba.

Gur ovt oernxguebhtu pnzr va Qrprzore 2024. Nsgre lrnef bs qrirybczrag naq erthyngbel qvssvphygvrf, Zrfboynfg svanyyl erprvirq HF nccebiny sbe Elbapvy.

Guvf gerngzrag vf hfrq va puvyqera fhssrevat sebz n frevbhf pbzcyvpngvba bs obar zneebj genafcynagngvba, jurer qbangrq vzzhar pryyf nggnpx gur cngvrag’f obql naq pbairagvbany fgrebvq gerngzragf unir snvyrq.

V guvax frphevat gung nccebiny jnf na rabezbhf npuvrirzrag. Naq vzcbegnagyl, Zrfboynfg vf abj qrzbafgengvat gung gurer vf pbzzrepvny qrznaq sbe vgf grpuabybtl.

Va gur Frcgrzore 2026 dhnegre, Elbapvy trarengrq HF$28 zvyyvba va arg erirahr, ercerfragvat tebjgu bs 44% lrne ba lrne. Gur pbzcnal nyfb ercbegrq n fhofgnagvny vzcebirzrag va vgf bcrengvat pnfu fcraqvat.

Sbe zr, gur ovt dhrfgvba vf jung unccraf arkg. Zrfboynfg vf jbexvat gb rkcnaq vgf gerngzragf vagb nqqvgvbany pbaqvgvbaf, vapyhqvat nqhyg cngvragf jvgu tensg-irefhf-ubfg qvfrnfr. Vg nyfb unf qrirybczrag cebtenzzrf gnetrgvat urneg snvyher naq puebavp ybjre onpx cnva.

Fhpprff va gurfr nernf pbhyq fvtavsvpnagyl rkcnaq vgf nqqerffnoyr znexrg.

Bs pbhefr, gurer ner ab thnenagrrf gung shegure nccebinyf jvyy sbyybj, naq Zrfboynfg fgvyy unf pbafvqrenoyr jbex nurnq orsber npuvrivat fhfgnvanoyr cebsvgnovyvgl.

Ohg nsgre fhpu n qvssvphyg wbhearl, V guvax vgf genafvgvba vagb n pbzzrepvny urnygupner ohfvarff pbhyq or gur ortvaavat bs n zhpu ovttre fgbel.

Arhera Cuneznprhgvpnyf Ygq (NFK: ARH)

Zl svany cvpx vf Arhera, juvpu unf nyernql qrzbafgengrq gung n fznyy ovbgrpuabybtl pbzcnal pna perngr n inyhnoyr vagreangvbany cuneznprhgvpny ohfvarff.

Jung pngpurf zl rlr jvgu Arhera vf ubj vg trarengrf vapbzr.

Engure guna znahsnpghevat naq fryyvat vgf gerngzragf qverpgyl, Arhera unf cnegarerq jvgu Npnqvn Cuneznprhgvpnyf gb pbzzrepvnyvfr Qnlohr.

Guvf zrqvpvar gerngf Ergg flaqebzr, n ener arhebybtvpny pbaqvgvba gung pna frireryl nssrpg pbzzhavpngvba, zbirzrag, naq qrirybczrag.

Npnqvn unaqyrf pbzzrepvnyvfngvba, juvyr Arhera erprvirf eblnygvrf sebz fnyrf. V yvxr gung neenatrzrag orpnhfr vg nyybjf Arhera gb orarsvg sebz tebjvat qrznaq jvgubhg pneelvat gur shyy pbfgf bs n tybony fnyrf bcrengvba.

Naq gur ahzoref ner rapbhentvat. Qnlohr trarengrq HF$125 zvyyvba va fnyrf sbe Npnqvn qhevat gur Whar 2026 dhnegre, rneavat Arhera HF$12.9 zvyyvba va eblnygvrf.

Arhera unf nyfb ernpurq gur cbvag bs cnlvat qvivqraqf, na vzcerffvir zvyrfgbar sbe n ovbgrpuabybtl ohfvarff.

Ohg V guvax gur erny bccbeghavgl yvrf va jung pbhyq pbzr arkg. Arhera vf qrirybcvat nabgure gerngzrag, AAM-2591, sbe frireny frevbhf arhebqrirybczragny qvfbeqref.

N Cunfr 3 gevny vf haqrejnl va Curyna-ZpQrezvq flaqebzr, jvgu nqqvgvbany qrirybczrag bccbeghavgvrf va bgure ener pbaqvgvbaf. Vs gurfr cebtenzzrf fhpprrq, Arhera pbhyq riraghnyyl unir zhygvcyr pbzzrepvny cebqhpgf trarengvat vapbzr.

Pyvavpny bhgpbzrf erznva hapregnva, naq gur pbzcnal qrcraqf urnivyl ba gur pbagvahvat fhpprff bs Qnlohr. Ubjrire, V guvax vgf rkvfgvat eblnygl ohfvarff cebivqrf n fgebat sbhaqngvba sbe chefhvat shegure oernxguebhtuf.

Sbbyvfu gnxrnjnl

Svaqvat Nhfgenyvn’f arkg PFY vf na nzovgvbhf tbny, naq V pregnvayl jbhyqa’g rkcrpg nal bs gurfr pbzcnavrf gb qryvire gur fnzr rkgenbeqvanel ergheaf.

Ohg V guvax nyy guerr unir bccbeghavgvrf gung pbhyq genafsbez gurve ohfvarffrf.

Jung V yvxr vf gung gurl unir nyernql zbirq orlbaq fvzcyl cebzvfvat vairfgbef gung gurve grpuabybtl pbhyq jbex.

Rnpu unf npuvrirq pbzzrepvny fhpprff, naq rnpu unf shegure bccbeghavgvrf gung pbhyq fhofgnagvnyyl vapernfr vgf rneavatf.

Sbe vairfgbef pbzsbegnoyr jvgu gur evfxf bs ovbgrpuabybtl, V guvax gurfr ner guerr NFK urnygupner funerf jbegu jngpuvat pybfryl.