Two men dead after trucks collide on Great Eastern Highway near Meckering, WA

Truck drivers have been killed in a catastrophic head-on collision that sparked a fire on a regional highway on Wednesday.

Two prime movers — one a white Volvo and the other a red and white Kenworth — towing semi-trailers crashed on Great Eastern Hwy near Quellington Rd, 130km east of Perth in Meckering, about 6.45am, WA Police said.

WATCH THE VIDEO ABOVE: Two truck drivers killed in horrific head-on crash east of Perth

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Four paramedic crews raced to the scene under priority one, St John Ambulance told 7NEWS.com.au.

Tragically, the 56-year-old male Volvo driver and the 33-year-old man behind the wheel of the Kenworth were critically injured and could not be saved.

It’s just a tragedy, and it’s a tragedy that occurs far too often in our industry,” Transport Workers Union WA assistant secretary Shane O’Brien said.

The two trucks were found fully engulfed in flames.

It took firefighters about an hour to get control of the blaze, the Department of Fire and Emergency Services told 7NEWS.com.au.

They worked with other emergency service personnel to control the scene and confirmed no hazardous materials were onboard either of the trucks involved.

“I’m sure it was very confronting,” WA Police Minister Reece Whitby said.

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“Our volunteers and community members do an amazing job and my thoughts are with those first responders who witnessed a very serious and horrific scene.”

Two trucks been found ablaze after colliding along the Great Eastern Hwy in Meckering, east of Perth, on Wednesday morning. Credit: 7NEWSIt’s understood two people have been critically injured in the crash. Credit: 7NEWS

Other motorists sounded the alarm about the morning crash with calls to triple-0.

Footage from the scene showed firefighters examining the smouldering wreckage.

The trailer of one truck could be seen perpendicular to the road, which the blaze had left charred and gutted the trailer of the second truck.

A stretch of Great Eastern Hwy remains closed and motorists have been urged to seek alternate routes.

O’Brien said transport is, statistically, the most dangerous industry in the country.

“On average a transport worker will die at work every week in this country,” he said.

WA Police’s Major Crash Unit have travelled to the scene and launched investigations into the incident.

Anyone with information or video relating to the crash should contact Crime Stoppers.