Detecting and quantifying clonal selection in somatic stem cells
Ethical approval Patient samples were collected with informed consent under the Mechanisms of Age-Related Clonal Haematopoiesis (MARCH) Study.…
Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial
Study design We conducted a prospective, randomized crossover trial to evaluate the real-world clinical impact of PEACH in…
Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design
Ethics statement This study complies with all relevant ethical regulations and was conducted in accordance with the research…
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
Cancer is a genetic disease stemming from a combination of inherited and acquired mutations. Much of our understanding…
Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs
Identifying the structures of autism phenotypes To best reflect the complexity of presentations across autistic individuals, we identified…
Overcoming regulatory barriers to the implementation of AI agents in healthcare – Nature
Overcoming regulatory barriers to the implementation of AI agents in healthcare NatureCan A.I. Find Cures for Untreatable Diseases—Using Drugs…