Limited overlap between genetic effects on disease susceptibility and disease survival
Ethics statement This study was conducted in compliance with the relevant ethical guidelines and approved by the appropriate…
Comparison of SHAP and clinician friendly explanations reveals effects on clinical decision behaviour
Introduction to the ‘pMSBOS-TS’ CDSS In our previous work, we introduced an AI algorithm named ‘precision maximum surgical…
TIMER: temporal instruction modeling and evaluation for longitudinal clinical records
Study design and data source Figure 1 summarizes the TIMER method for instruction-tuning and evaluating temporal reasoning capabilities…
Validation of a long-term and effective physical exercise management for ankylosing spondylitis: study protocol for a decentralized randomized controlled trial | Trials
Explanation for the choice of comparators {6b} The intervention group is managed by “Exercise Management Mode based on…
Bryophytes hold a larger gene family space than vascular plants
Kenrick, P. & Crane, P. R. The origin and early evolution of plants on land. Nature 389, 33–39…
Reticulocalbin-1 in clear cell renal cell carcinoma: clinical and functional evidence for its role as a biomarker and potential therapeutic target | BMC Cancer
Despite therapeutic advancements, the prognosis for metastatic ccRCC remains poor, with a 5-year survival rate of approximately 12–20…
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects
Abul-Husn, N. S. & Kenny, E. E. Personalized medicine and the power of electronic health records. Cell 177,…
Is enhancer-driven gene regulation all wrapped up?
Symmons, O. et al. The Shh topological domain facilitates the action of remote enhancers by reducing the effects…
Regulatory genome annotation | Nature Reviews Genetics
Gerstein, M. B. et al. Architecture of the human regulatory network derived from ENCODE data. Nature 489, 91–100…
Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions
Study design and data sources The data used in this study are collected and used in line with…
Synthetic lethality in cancer drug discovery: challenges and opportunities
Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W. & Friend, S. H. Integrating genetic approaches…
A genome-wide association analysis reveals new pathogenic pathways in gout
Kuo, C. F. et al. Global epidemiology of gout: prevalence, incidence and risk factors. Nat. Rev. Rheumatol. 11,…