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Browsing Tag

Biomedicine

80 posts
GGenetics
Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases
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Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases

  • July 25, 2025
Single-cell multiome dataset Single-cell multiome (snRNA-seq + snATAC-seq) data of the human left ventricle and lung were processed and clustered…
GGenetics
Detecting and quantifying clonal selection in somatic stem cells
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Detecting and quantifying clonal selection in somatic stem cells

  • July 24, 2025
Ethical approval Patient samples were collected with informed consent under the Mechanisms of Age-Related Clonal Haematopoiesis (MARCH) Study.…
HHealthcare
Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial
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Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial

  • July 23, 2025
Study design We conducted a prospective, randomized crossover trial to evaluate the real-world clinical impact of PEACH in…
GGenetics
Experimental evolution in an era of molecular manipulation
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Experimental evolution in an era of molecular manipulation

  • July 21, 2025
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
GGenetics
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design
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Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design

  • July 19, 2025
Ethics statement This study complies with all relevant ethical regulations and was conducted in accordance with the research…
GGenetics
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
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Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy

  • July 19, 2025
Cancer is a genetic disease stemming from a combination of inherited and acquired mutations. Much of our understanding…
GGenetics
Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs
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Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs

  • July 19, 2025
Identifying the structures of autism phenotypes To best reflect the complexity of presentations across autistic individuals, we identified…
HHealthcare
Overcoming regulatory barriers to the implementation of AI agents in healthcare - Nature
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Overcoming regulatory barriers to the implementation of AI agents in healthcare – Nature

  • July 18, 2025
Overcoming regulatory barriers to the implementation of AI agents in healthcare  NatureCan A.I. Find Cures for Untreatable Diseases—Using Drugs…
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