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Browsing Tag

CD4

11 posts
HHealth
Gut infection leaves long-lasting immune ‘memories’ at the brain’s borders in mice
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Gut infection leaves long-lasting immune ‘memories’ at the brain’s borders in mice

  • September 10, 2026
A mouse study traces how immune cells activated in the intestine migrate to the dura and persist at…
TTechnology
Prebiotic fiber supplement lowers pain sensitivity in people with knee osteoarthritis
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Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

  • May 23, 2026
The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which…
HHealth
Genetic clustering of swine influenza revealed in Northern Italy
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Nasal memory cells help slow influenza virus at entry

  • April 24, 2026
Memory cells in the nose slow the influenza virus as soon as it enters the body. They reduce…
HHealth
Scientists reveal how the body senses cold and menthol
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Hidden viral reservoirs in tonsils may explain school-year respiratory outbreaks

  • April 17, 2026
A study conducted at the University of São Paulo (USP) in Brazil reveals that tissues such as the…
HHealth
Innate immune activation and microglial transition during neurodegeneration. (A) During neurodegeneration, distressed neurons release DAMPs such as mtDNA, ROS, HMGB1, aberrant proteins, and pTau–bound RNA. These signals activate resident microglia and astrocytes, which then recruit peripheral immune cells. As shown in more detail in B, activated microglia upregulate PRRs, including TLRs, RAGE, and cGAS, enabling detection of neuron-derived DAMPs. Engagement of PRRs induces proinflammatory gene expression programs and activates inflammasome pathways that promote release of chemokines and cytokines into the CNS parenchyma. As microglia transition from homeostatic to reactive states in a TREM2-dependent manner, damage-associated microglia increase MHC-II expression to support antigen presentation and coordination of adaptive immune responses that attempt to limit neurodegeneration.
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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

  • April 17, 2026
A sweeping review shows how the brain’s immune defenses can both fight and fuel neurodegeneration, revealing why timing,…
HHealth
Leading organizations announce research initiative to uncover why ALS affects high-performing populations
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Gut immune responses found to trigger brain inflammation in MS

  • March 28, 2026
Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and…
HHealth
Maldives achieves historic triple elimination of mother-to-child transmission of diseases
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Researchers explore “block and lock” strategy for functional HIV cure

  • March 23, 2026
For millions of people living with HIV, a daily regimen of medications is a lifelong necessity. If they…
HHealth
Study: Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC. Image Credit: Guschenkova / Shutterstock
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Precision mRNA vaccine strategy shows early promise for improving TNBC relapse risk

  • February 20, 2026
A pioneering personalized mRNA vaccine study reveals lasting immune responses in triple-negative breast cancer, offering early signals that…
TTechnology
IRF-5 identified as key to preventing immune cell exhaustion
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Engineered extracellular vesicles enable antigen-specific regulatory T cell induction

  • December 23, 2025
A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University…
HHealth
Study: Dietary iron deficiency impairs effector function of memory T cells following influenza infection. Image Credit: Corona Borealis Studio  / Shutterstock
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Poor dietary iron weakens lung memory T cells after flu infection

  • December 8, 2025
Even when immune memory cells form in the lung after influenza infection, insufficient dietary iron leaves them less…
HHealth
Common food additives may trigger childhood asthma
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Common food additives may trigger childhood asthma

  • October 6, 2025
A recent study published in Frontiers in Immunology utilized metabolomics to investigate the mechanisms underlying the association between food…
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