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Browsing Tag

Cell Death

13 posts
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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Reframing the role of MCL1 in cancer signaling and metabolism

  • December 23, 2025
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Efficacy of methylprednisolone doses in severe Mycoplasma Pneumonia
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Bacterial enzyme linked to heart complications in pneumonia

  • December 5, 2025
Pneumonia is a disease that burdens the healthcare system with more that 1.2 million emergency room visits each…
HHealth
Middle precentral gyrus plays key role in orchestrating speech movements
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Understanding how adult brains adapt to challenge and change

  • December 4, 2025
In a revelatory Genomic Press Interview published today in Brain Medicine, Dr. Paul Lucassen, full professor at the…
SScience
Innate immunity and metabolic stress drive a unique form of cell death
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Innate immunity and metabolic stress drive a unique form of cell death

  • December 2, 2025
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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Triaptosis-based therapeutic innovations could offer renewed hope for cancer patients

  • December 1, 2025
Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens…
HHealth
Process of making tattoo close-up
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Tattoo ink alters immune cells and weakens some vaccine responses

  • November 27, 2025
New research reveals that tattoo pigments don’t just stay in the skin, they migrate into lymph nodes, trigger…
HHealth
Intelligent learning can accelerate global efforts to prevent cervical cancer
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Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

  • November 1, 2025
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
HHealth
Variety of processed cold red meat products.
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How processed red meat might drive neurodegenerative diseases

  • September 15, 2025
Scientists warn that while processed red meat may fuel harmful brain changes linked to Alzheimer’s, Parkinson’s, and ALS,…
HHealth
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
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Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk

  • September 13, 2025
Researchers have identified the mechanism by which a common genetic mutation increases liver disease risk. Their findings suggest…
GGenetics
New genetic discovery could change how Friedreich's ataxia is diagnosed
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Australian scientists uncover new way to halt aggressive cancer growth

  • July 28, 2025
Australian researchers have discovered a promising new strategy to suppress the growth of aggressive and hard-to-treat cancers by…
HHealth
Study: Inhibition of GAPDH aggregation as a potential treatment for acute ischemic stroke. Image Credit: crystal light / Shutterstock
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Blocking GAPDH aggregation protects brain cells and opens new path for stroke therapy

  • July 21, 2025
A novel study reveals that targeting a single protein’s aggregation can dramatically reduce brain injury after stroke, potentially…
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