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Browsing Tag

Cell Death

18 posts
HHealth
Early-onset pancreatic cancer patients benefit more from neoadjuvant chemotherapy and surgery
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Tumor microenvironment drives resistance to ferroptosis in pancreatic cancer

  • April 3, 2026
Tumors driven by cancer-driving KRAS mutations are often susceptible to ferroptosis, a type of cell death that can…
HHealth
Study: Palmatine ameliorates MASLD in type 2 diabetes by modulating hepatic apoptosis and inflammation. Image Credit: sasirin pamai / Shutterstock
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Palmatine improved fatty liver markers in a preclinical type 2 diabetes study

  • March 24, 2026
A new preclinical study suggests that palmatine may ease diabetes-linked fatty liver disease by targeting inflammation, oxidative stress,…
HHealth
Corneas from diabetic donors perform well in vision restoring surgeries
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Chlamydia pneumoniae found in the eye may aggravate Alzheimer’s disease

  • February 2, 2026
Chlamydia pneumoniae—a common bacterium that causes pneumonia and sinus infections—can linger in the eye and brain for years…
SScience
Dual pathways found for centromere specification, ensuring accurate chromosome segregation
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Dual pathways found for centromere specification, ensuring accurate chromosome segregation

  • January 8, 2026
Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans,…
HHealth
New therapeutic approach targets undruggable protein driving aggressive breast cancer
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Study reveals a therapeutic vulnerability in aggressive subtype of triple-negative breast cancer

  • December 27, 2025
Dec 26 2025 A new study published today in Science Translational Medicine by researchers at The University of…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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Reframing the role of MCL1 in cancer signaling and metabolism

  • December 23, 2025
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD…
HHealth
Cellular responses to ischemic reperfusion injury in young vs older donor organs. During ischemia, the deprivation of oxygen and nutrients leads to mitochondrial dysfunction and energy loss. In young cells, mitochondrial resilience helps sustain ATP production, ameliorating damage. Old cells, in contrast, experience significant ATP depletion, relying heavily on anaerobic metabolism, which leads to lactate buildup, pH reduction, and cellular stress. Upon reperfusion, the restoration of blood flow triggers oxidative stress as mitochondria generate excessive reactive oxygen species (ROS). Young cells compensate for those events through robust antioxidant systems, maintaining cellular integrity. Conversely, in old cells, impaired antioxidant defenses result in unregulated ROS production, furthermore damaging membranes, organelles, and DNA. Additionally, old cells release pro-inflammatory genes, amplifying local inflammation. Consequences are particularly severe in aged vascular endothelial cells, with ion pump dysfunction (e.g., Na⁺/K⁺ ATPase) causing ionic imbalances and cellular edema. This disruption exacerbates ischemic injury, progressing to irreversible damage. In contrast, young cells effectively resolve edema and inflammation through mechanisms that include macrophage945 mediated clearance of Damage-Associated Molecular Patterns (DAMPs) and anti-inflammatory cytokine release (e.g., IL-10 and TGF-β), allowing recovery and tissue repair. In old cells, persistent ROS generation, unresolved inflammation, and DAMP accumulation lead to irreversible inflammation, organelle collapse, and eventual cell death. Created in BioRender. Kayumov, M. (2025) https://BioRender.com/m23u7ro .
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Scientists outline how organ rejuvenation strategies could solve the donor shortage

  • December 12, 2025
New insights into cellular aging, perfusion technologies, and senescence-targeting treatments show how aging organs could be revived, turning…
HHealth
Efficacy of methylprednisolone doses in severe Mycoplasma Pneumonia
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Bacterial enzyme linked to heart complications in pneumonia

  • December 5, 2025
Pneumonia is a disease that burdens the healthcare system with more that 1.2 million emergency room visits each…
HHealth
Middle precentral gyrus plays key role in orchestrating speech movements
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Understanding how adult brains adapt to challenge and change

  • December 4, 2025
In a revelatory Genomic Press Interview published today in Brain Medicine, Dr. Paul Lucassen, full professor at the…
SScience
Innate immunity and metabolic stress drive a unique form of cell death
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Innate immunity and metabolic stress drive a unique form of cell death

  • December 2, 2025
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study…
HHealth
New approach doubles chemotherapy effectiveness by targeting cancer cell memory
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Triaptosis-based therapeutic innovations could offer renewed hope for cancer patients

  • December 1, 2025
Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens…
HHealth
Process of making tattoo close-up
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Tattoo ink alters immune cells and weakens some vaccine responses

  • November 27, 2025
New research reveals that tattoo pigments don’t just stay in the skin, they migrate into lymph nodes, trigger…
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